Regulski M, Harding K, Kostriken R, Karch F, Levine M, McGinnis W
Cell. 1985 Nov;43(1):71-80. doi: 10.1016/0092-8674(85)90013-3.
The Antennapedia, Ultrabithorax, and fushi tarazu genes of Drosophila melanogaster each contain a very similar protein coding sequence, the homeo box. Previously cloned homeo box sequences were used to isolate additional well conserved members of the homeo box gene family. The most strongly conserved members of the homeo box gene family map within either the Antennapedia or Bithorax gene complexes. The tissue distribution of transcripts encoded by the two rightmost homeo box genes of the Bithorax complex are compared with the iab-2 and iab-7 phenotypes.
黑腹果蝇的触角足基因、超双胸基因和腹节基因各自都包含一个非常相似的蛋白质编码序列,即同源异型框。先前克隆的同源异型框序列被用于分离同源异型框基因家族中其他高度保守的成员。同源异型框基因家族中保守性最强的成员定位于触角足基因复合体或双胸基因复合体中。将双胸基因复合体最右侧的两个同源异型框基因所编码转录物的组织分布与iab - 2和iab - 7表型进行了比较。