Kawabori S, Okuda M, Unno T, Nakamura A
Clin Allergy. 1985 Nov;15(6):509-15. doi: 10.1111/j.1365-2222.1985.tb02303.x.
The histamine content in the nasal epithelial layer of twenty-five patients with nasal allergy was measured before, 10 min after and 1 hr after nasal provocation with allergen. A decrease in histamine content was observed 10 min after provocation compared to the values obtained before provocation (P less than 0.05). There was a tendency for an increase in the histamine content of the nasal epithelium one hour after provocation when compared with the amounts present 10 min after provocation (P less than 0.1). Mast cells in the nasal epithelial layer of a further five patients were studied by electron microscopy 10 min and 1 hr after provocation. The rate of mast cell degranulation appeared to decrease 1 hr after provocation when compared with 10 min. Our study suggests that some mast cells commence their migration to the nasal epithelial layer over a short time period and that they may play a role in the onset of the allergic nasal reaction in patients with allergic nasal symptoms.
对25名鼻过敏患者的鼻上皮层组胺含量在过敏原鼻激发前、激发后10分钟和激发后1小时进行了测量。与激发前获得的值相比，激发后10分钟观察到组胺含量降低（P<0.05）。与激发后10分钟时的含量相比，激发后1小时鼻上皮的组胺含量有增加的趋势（P<0.1）。另外5名患者在激发后10分钟和1小时通过电子显微镜研究了鼻上皮层中的肥大细胞。与10分钟时相比，激发后1小时肥大细胞脱颗粒率似乎降低。我们的研究表明，一些肥大细胞在短时间内开始迁移到鼻上皮层，并且它们可能在有过敏性鼻症状的患者的过敏性鼻反应发作中起作用。
