米诺环素-利福平浸渍导管序贯包被氯己定预防革兰氏阴性菌生物膜定植。
Prevention of biofilm colonization by Gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine.
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2014;58(2):1179-82. doi: 10.1128/AAC.01959-13. Epub 2013 Oct 28.
Abstract
Resistant Gram-negative bacteria are increasing central-line-associated bloodstream infection threats. To better combat this, chlorhexidine (CHX) was added to minocycline-rifampin (M/R) catheters. The in vitro antimicrobial activity of CHX-M/R catheters against multidrug resistant, Gram-negative Acinetobacter baumannii, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia was tested. M/R and CHX-silver sulfadiazine (CHX/SS) catheters were used as comparators. The novel CHX-M/R catheters were significantly more effective (P < 0.0001) than CHX/SS or M/R catheters in preventing biofilm colonization and showed better antimicrobial durability.
摘要
耐药革兰氏阴性菌增加了中心静脉相关血流感染的威胁。为了更好地应对这一威胁，将洗必泰（CHX）添加到米诺环素-利福平（M/R）导管中。测试了 CHX-M/R 导管对多药耐药革兰氏阴性鲍曼不动杆菌、阴沟肠杆菌、大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌和嗜麦芽窄食单胞菌的体外抗菌活性。将 M/R 和 CHX-磺胺嘧啶银（CHX/SS）导管用作对照。新型 CHX-M/R 导管在预防生物膜定植方面明显比 CHX/SS 或 M/R 导管更有效（P<0.0001），并且具有更好的抗菌耐久性。
相似文献
1
Prevention of biofilm colonization by Gram-negative bacteria on minocycline-rifampin-impregnated catheters sequentially coated with chlorhexidine.
Antimicrob Agents Chemother. 2014;58(2):1179-82. doi: 10.1128/AAC.01959-13. Epub 2013 Oct 28.
2
Improved antibiotic-impregnated catheters with extended-spectrum activity against resistant bacteria and fungi.
Antimicrob Agents Chemother. 2012 Feb;56(2):935-41. doi: 10.1128/AAC.05836-11. Epub 2011 Nov 28.
3
In Vitro Assessment of the Antimicrobial Efficacy of Optimized Nitroglycerin-Citrate-Ethanol as a Nonantibiotic, Antimicrobial Catheter Lock Solution for Prevention of Central Line-Associated Bloodstream Infections.
Antimicrob Agents Chemother. 2016 Aug 22;60(9):5175-81. doi: 10.1128/AAC.00254-16. Print 2016 Sep.
4
In vivo biocompatibility and in vitro efficacy of antimicrobial gendine-coated central catheters.
Antimicrob Agents Chemother. 2015 Sep;59(9):5611-8. doi: 10.1128/AAC.00834-15. Epub 2015 Jun 29.
5
The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin.
J Infect Dis. 1996 Feb;173(2):418-24. doi: 10.1093/infdis/173.2.418.
6
In vitro activity of antimicrobial-impregnated catheters against biofilms formed by KPC-producing Klebsiella pneumoniae.
J Appl Microbiol. 2019 Oct;127(4):1018-1027. doi: 10.1111/jam.14372. Epub 2019 Jul 30.
7
Anti-adherence activity and antimicrobial durability of anti-infective-coated catheters against multidrug-resistant bacteria.
J Antimicrob Chemother. 2008 Oct;62(4):746-50. doi: 10.1093/jac/dkn281. Epub 2008 Jul 23.
8
Prevention of transmission of multidrug-resistant organisms during catheter exchange using antimicrobial catheters.
Antimicrob Agents Chemother. 2014 Sep;58(9):5291-6. doi: 10.1128/AAC.02886-14. Epub 2014 Jun 23.
9
Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections.
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.02596-16. Print 2017 Jun.
10
Antibiotics and prevention of microbial colonization of catheters.
Antimicrob Agents Chemother. 1995 Nov;39(11):2397-400. doi: 10.1128/AAC.39.11.2397.
引用本文的文献
1
Risk factors for catheter-related bloodstream infections in a high-risk cancer patient population.
Infect Control Hosp Epidemiol. 2025 May 26;46(7):1-4. doi: 10.1017/ice.2025.45.
2
Incorporating Ceragenins into Coatings Protects Peripherally Inserted Central Catheter Lines against Pathogen Colonization for Multiple Weeks.
Int J Mol Sci. 2023 Oct 5;24(19):14923. doi: 10.3390/ijms241914923.
3
Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core-Shell Electrospun Membranes: A Proof of Concept.
ACS Appl Mater Interfaces. 2022 Jun 22;14(24):27599-27612. doi: 10.1021/acsami.2c04849. Epub 2022 Jun 7.
4
Advances in the Microbiology of Stenotrophomonas maltophilia.
Clin Microbiol Rev. 2021 Jun 16;34(3):e0003019. doi: 10.1128/CMR.00030-19. Epub 2021 May 26.
5
Combination inhibition activity of chlorhexidine and antibiotics on multidrug-resistant Acinetobacter baumannii in vitro.
BMC Infect Dis. 2021 Mar 17;21(1):266. doi: 10.1186/s12879-021-05963-6.
6
Slippery liquid infused fluoropolymer coating for central lines to reduce catheter associated clotting and infections.
Sci Rep. 2020 Sep 11;10(1):14973. doi: 10.1038/s41598-020-71711-6.
7
Assessment of the Potential for Inducing Resistance in Multidrug-Resistant Organisms from Exposure to Minocycline, Rifampin, and Chlorhexidine Used To Treat Intravascular Devices.
Antimicrob Agents Chemother. 2019 Apr 25;63(5). doi: 10.1128/AAC.00040-19. Print 2019 May.
8
Anti-fouling strategies for central venous catheters.
Cardiovasc Diagn Ther. 2017 Dec;7(Suppl 3):S246-S257. doi: 10.21037/cdt.2017.09.18.
9
Study of Antimicrobial Percutaneous Nephrostomy Catheters for Prevention of Renal Infections.
Antimicrob Agents Chemother. 2017 May 24;61(6). doi: 10.1128/AAC.02596-16. Print 2017 Jun.
10
Inactivation of Acinetobacter baumannii Biofilms on Polystyrene, Stainless Steel, and Urinary Catheters by Octenidine Dihydrochloride.
Front Microbiol. 2016 Jun 9;7:847. doi: 10.3389/fmicb.2016.00847. eCollection 2016.
本文引用的文献
1
Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010.
Infect Control Hosp Epidemiol. 2013 Jan;34(1):1-14. doi: 10.1086/668770. Epub 2012 Nov 27.
2
Improved antibiotic-impregnated catheters with extended-spectrum activity against resistant bacteria and fungi.
Antimicrob Agents Chemother. 2012 Feb;56(2):935-41. doi: 10.1128/AAC.05836-11. Epub 2011 Nov 28.
3
Bacteraemia due to multidrug-resistant Gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes.
J Antimicrob Chemother. 2011 Mar;66(3):657-63. doi: 10.1093/jac/dkq494. Epub 2010 Dec 29.
4
Epidemiologic, clinical characteristics, and risk factors for adverse outcome in multiresistant gram-negative primary bacteremia of critically ill patients.
Am J Infect Control. 2011 Jun;39(5):396-400. doi: 10.1016/j.ajic.2010.06.017. Epub 2010 Oct 30.
5
The clinical effectiveness of central venous catheters treated with anti-infective agents in preventing catheter-related bloodstream infections: a systematic review.
Crit Care Med. 2009 Feb;37(2):702-12. doi: 10.1097/CCM.0b013e3181958915.
6
NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007.
Infect Control Hosp Epidemiol. 2008 Nov;29(11):996-1011. doi: 10.1086/591861.
7
Anti-adherence activity and antimicrobial durability of anti-infective-coated catheters against multidrug-resistant bacteria.
J Antimicrob Chemother. 2008 Oct;62(4):746-50. doi: 10.1093/jac/dkn281. Epub 2008 Jul 23.
8
A systematic review comparing the relative effectiveness of antimicrobial-coated catheters in intensive care units.
Am J Infect Control. 2008 Mar;36(2):104-17. doi: 10.1016/j.ajic.2007.02.012.
9
Intravascular catheter-related infections: advances in diagnosis, prevention, and management.
Lancet Infect Dis. 2007 Oct;7(10):645-57. doi: 10.1016/S1473-3099(07)70235-9.
10
Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm.
Antimicrob Agents Chemother. 2007 May;51(5):1656-60. doi: 10.1128/AAC.00350-06. Epub 2007 Mar 12.
Zotero 插件