Raad I, Darouiche R, Hachem R, Mansouri M, Bodey G P
Section of Infectious Diseases, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
J Infect Dis. 1996 Feb;173(2):418-24. doi: 10.1093/infdis/173.2.418.
The in vitro and in vivo activities of catheters coated with minocycline and rifampin and with chlorhexidine gluconate and silver sulfadiazine were evaluated. When incubated in serum at 37 degrees C, the half-life of the inhibitory activity of catheters coated with minocycline and rifampin was 25 days compared with 3 days for catheters coated with chlorhexidine gluconate and silver sulfadiazine. In a rabbit model, catheters coated with minocycline and rifampin were significantly more efficacious than catheters coated with chlorhexidine and silver sulfadiazine in preventing colonization and infection with Staphylococcus aureus (P < .05). Catheters coated with minocycline and rifampin demonstrated broad-spectrum in vitro inhibitory activity against gram-positive bacteria, gram-negative bacteria, and Candida albicans that was significantly superior to the inhibitory activity of catheters coated with chlorhexidine gluconate and silver sulfadiazine (P < .01). Minocycline and rifampin were also highly efficacious in preventing colonization and infection in vivo.
对涂有米诺环素和利福平以及涂有葡萄糖酸洗必泰和磺胺嘧啶银的导管的体外和体内活性进行了评估。在37℃血清中孵育时，涂有米诺环素和利福平的导管的抑制活性半衰期为25天，而涂有葡萄糖酸洗必泰和磺胺嘧啶银的导管为3天。在兔模型中，涂有米诺环素和利福平的导管在预防金黄色葡萄球菌定植和感染方面比涂有葡萄糖酸洗必泰和磺胺嘧啶银的导管显著更有效（P<0.05）。涂有米诺环素和利福平的导管对革兰氏阳性菌、革兰氏阴性菌和白色念珠菌表现出广谱体外抑制活性，显著优于涂有葡萄糖酸洗必泰和磺胺嘧啶银的导管的抑制活性（P<0.01）。米诺环素和利福平在体内预防定植和感染方面也非常有效。
