衔接蛋白 Crk 在免疫反应中的作用。
The adaptor protein Crk in immune response.
机构信息
1] Center for Human Immunobiology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA [2] Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
出版信息
Immunol Cell Biol. 2014 Jan;92(1):80-9. doi: 10.1038/icb.2013.64. Epub 2013 Oct 29.
The adaptor proteins Crk (CT10 (chicken tumor virus number 10) regulator of kinase), including CrkI, CrkII and Crk-like, are important signal molecules that regulate a variety of cellular processes. Considerable progress has been made in understanding the roles of the Crk family proteins in signal transduction, with a focus on cellular transformation and differentiation. However, since Crk was identified in 1988, very few studies have addressed how Crk regulates the immune response. Recent work demonstrates that Crk proteins function as critical signal molecules in regulating immune cell functions. Emerging data on the roles of Crk in activation and inhibitory immunoreceptor signaling suggest that Crk proteins are potential immunotherapeutic targets in cancer and infectious diseases. The aim of this review is to summarize recent key findings regarding the role of Crk in immune responses mediated by T, B and natural killer (NK) cells. In particular, the roles of Crk in NK cell functions are discussed.
衔接蛋白 Crk（鸡肿瘤病毒 10 号的激酶调节剂 CT10），包括 CrkI、CrkII 和 Crk 样蛋白，是调节多种细胞过程的重要信号分子。在理解 Crk 家族蛋白在信号转导中的作用方面已经取得了相当大的进展，重点是细胞转化和分化。然而，自从 1988 年发现 Crk 以来，很少有研究探讨 Crk 如何调节免疫反应。最近的工作表明，Crk 蛋白在调节免疫细胞功能方面起着关键信号分子的作用。Crk 在激活和抑制免疫受体信号转导中的作用的新数据表明，Crk 蛋白是癌症和传染病免疫治疗的潜在靶点。本文综述了 Crk 在 T、B 和自然杀伤（NK）细胞介导的免疫反应中的作用的最新关键发现。特别是，讨论了 Crk 在 NK 细胞功能中的作用。
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