甲基四氢叶酸-同型半胱氨酸甲基转移酶（MTR）A2756G多态性与乳腺癌风险的作用。
Role of polymorphism of methyltetrahydrofolate-homocysteine methyltransferase (MTR) A2756G and breast cancer risk.
作者信息
Hosseini Mojgan
机构信息
Mojgan Hosseini PhD, Department of Science, Islamshahr Branch, Islamic Azad University, Sayad Shirazi, St. Islamshahr, Tehran, Iran, tel./fax +98-21-66936779, e-mail:
出版信息
Pol J Pathol. 2013 Oct;64(3):191-5. doi: 10.5114/pjp.2013.38138.
Breast cancer (BC) is one of the most common causes of death among women, and second in Iran. The objectives of this study were to determine the frequency of methyltetrahydrofolate-homocysteine methyltransferase (MTR) 2756 gene polymorphism in patients with breast cancer. For the first time, we evaluated these polymorphisms and effects on the breast cancer risk association in an Iranian sporadic population-based case-control study of 282 breast cancer cases and 310 controls using a PCR-RFLP-based assay. Analyses of affected and controls show that homozygote genotype MTR 2756 AA has the highest frequency in both groups (33.3 in patients). Genotype MTR 2756 GG was the highest risk factor in our population [AG/GG odds ratio, 0.329 (95% CI: 0.146-0.741) p = 0.006, AA/AG, OR, 2.316, 95% CI: 1.509-3.555, p = 0.001, AA/GG odds ratio, 0.761 (95% CI: 0.363-1.595) p = 0.297]. There was a significant association of breast cancer risk with MTR 2756 GG and AA polymorphism.
乳腺癌（BC）是女性中最常见的死亡原因之一，在伊朗位列第二。本研究的目的是确定乳腺癌患者中甲基四氢叶酸-同型半胱氨酸甲基转移酶（MTR）2756基因多态性的频率。在一项基于伊朗散发性人群的病例对照研究中，我们首次使用基于聚合酶链反应-限制性片段长度多态性（PCR-RFLP）的检测方法，对282例乳腺癌病例和310例对照进行了这些多态性及其与乳腺癌风险关联影响的评估。对病例组和对照组的分析表明，纯合子基因型MTR 2756 AA在两组中频率最高（患者组为33.3%）。基因型MTR 2756 GG是我们研究人群中最高的风险因素[AG/GG比值比，0.329（95%置信区间：0.146 - 0.741），p = 0.006；AA/AG，比值比，2.316，95%置信区间：1.509 - 3.555，p = 0.001；AA/GG比值比，0.761（95%置信区间：0.363 - 1.595），p = 0.297]。乳腺癌风险与MTR 2756 GG和AA多态性之间存在显著关联。
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