Guenin R, Schneider C H
Int Arch Allergy Appl Immunol. 1986;79(1):49-52. doi: 10.1159/000233941.
N1-DNCP-N6-lactobionoyl-1,6-hexanediamine is an elicitor of anaphylactic reactions in the guinea pig passively sensitized by antisera raised with a DNCP-bovine gammaglobulin conjugate. If the antisera contained anticarbohydrate antibodies against the carbohydrate residues of the globulin, significantly cross-reacting with the lactobionoyl moiety, anaphylactogenic cell triggering would be by classical hetero-specific bridging which involved the DNCP- and the lactobionoyl residues as ligands. This possibility was excluded by showing that a bis-lactobionoyl conjugate is unable to elicit anaphylactic reactions.
N1 - 二硝基氯苯 - N6 - 乳糖二酰基 - 1,6 - 己二胺是一种能在由用二硝基氯苯 - 牛γ球蛋白偶联物免疫产生的抗血清被动致敏的豚鼠中引发过敏反应的激发剂。如果抗血清含有针对球蛋白碳水化合物残基的抗碳水化合物抗体，且与乳糖二酰基部分有显著交叉反应，那么过敏反应性细胞触发将通过经典的异特异性桥联发生，其中二硝基氯苯残基和乳糖二酰基残基作为配体。通过证明双乳糖二酰基偶联物不能引发过敏反应排除了这种可能性。
