从化学角度看转录保真度：无锁定核酸揭示糖完整性的主要贡献。
A chemical perspective on transcriptional fidelity: dominant contributions of sugar integrity revealed by unlocked nucleic acids.
机构信息
Skaggs School of Pharmacy and Pharmaceutical Sciences, The University of California, San Diego, La Jolla, CA 92093-0625 (USA).
出版信息
Angew Chem Int Ed Engl. 2013 Nov 18;52(47):12341-5. doi: 10.1002/anie.201307661. Epub 2013 Oct 24.
Abstract
Transcription unlocked: A synthetic chemical biology approach involving unlocked nucleic acids was used to dissect the contribution of sugar backbone integrity to the RNA Polymerase II (Pol II) transcription process. An unexpected dominant role for sugar-ring integrity in Pol II transcriptional efficiency and fidelity was revealed.
摘要
转录解锁
涉及非锁核酸的合成化学生物学方法被用于剖析糖骨架完整性对 RNA 聚合酶 II（Pol II）转录过程的贡献。结果揭示了糖环完整性在 Pol II 转录效率和保真度中出人意料的主导作用。
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