Lee S J, Harpur E S
Hear Res. 1985;20(1):37-43. doi: 10.1016/0378-5955(85)90057-7.
The DC endocochlear potential and the AC cochlear potential in response to a 4 kHz tone were recorded in pigmented guinea pigs before and during ototoxic damage induced by sequential administration of the aminoglycoside antibiotic, gentamicin, and the loop diuretic, furosemide. Within 4 h significant diminution of the amplitude of the AC cochlear potential was accompanied by an almost complete abolition of the negative diffusion potential revealed by either furosemide administration or terminal anoxia. Thus, one of the effects of this interaction appears to involve a reduction in the potassium permeability of the cochlear partitions.
在对有色豚鼠连续给予氨基糖苷类抗生素庆大霉素和袢利尿剂速尿诱导耳毒性损伤之前和期间，记录了其对4kHz音调的直流内耳蜗电位和交流耳蜗电位。在4小时内，交流耳蜗电位的幅度显著减小，同时，无论是给予速尿还是终末缺氧所揭示的负扩散电位几乎完全消失。因此，这种相互作用的影响之一似乎涉及耳蜗隔板钾通透性的降低。
