Laurell G, Engström B
Institute of Physiology II, Karolinska Institute, Stockholm, Sweden.
Hear Res. 1989 Mar;38(1-2):19-26. doi: 10.1016/0378-5955(89)90124-x.
The effect of the combined administration of cisplatin and furosemide on the electrophysiological hearing thresholds and endocochlear DC potential (EP) was studied in guinea pigs. A lack of interaction was found in animals given repeated intraperitoneal injections of a low dose of cisplatin with a pharmacological dose of furosemide. An ototoxic interaction occurred when a moderately high dose of cisplatin was administered intravenously at a time when the strial function was most affected by a very high dose of furosemide. The interaction was seen both as a decreased EP and a pronounced shift of auditory thresholds. It is concluded that the stria vascularis plays a role in the ototoxic mechanism of cisplatin.
研究了顺铂与呋塞米联合给药对豚鼠电生理听力阈值和内淋巴直流电电位（EP）的影响。在反复腹腔注射低剂量顺铂与药理剂量呋塞米的动物中未发现相互作用。当在血管纹功能受非常高剂量呋塞米影响最大时静脉注射中等高剂量顺铂时，发生了耳毒性相互作用。这种相互作用表现为EP降低和听觉阈值明显偏移。结论是血管纹在顺铂的耳毒性机制中起作用。
