National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia and Australian Mesothelioma Tissue Bank, Sir Charles Gairdner Hospital, Perth, WA 6009, Australia.
Dis Markers. 2013;35(2):119-27. doi: 10.1155/2013/874212. Epub 2013 Aug 6.
The MSLN gene products, soluble mesothelin and megakaryocyte potentiating factor (MPF), are being investigated as biomarkers for the asbestos-related cancer malignant mesothelioma (MM). Pleural fluid biomarkers of MM can be elevated when serum levels remain normal. The aim of this study was to determine if this was true for MPF and to compare levels of mesothelin. Biomarker concentrations were compared in 66 MM patients, 39 patients with other malignancies, 37 with benign disease, 18 asbestos-exposed healthy individuals, and 53 patients with chronic kidney disease. In pleural effusions, MPF and soluble mesothelin concentrations were both significantly elevated in MM patients relative to controls. No significant difference between the area under the receiver operator curve (AUC) for MPF (0.945 ± 0.02) and mesothelin (0.928 ± 0.03) when distinguishing MM from all other causes of effusion was observed. MPF and mesothelin serum concentrations were highly correlated and of equivalent diagnostic accuracy with AUCs of 0.813 ± 0.04 and 0.829 ± 0.03, respectively. Serum levels of both markers increased with decreasing kidney function. In conclusion, MPF is elevated in the pleural effusions of MM patients similar to that of mesothelin. Mesothelin and MPF convey equivalent diagnostic information for distinguishing MM from other diseases in pleural effusions as well as serum.
MSLN 基因产物，可溶性间皮素和巨核细胞促成熟因子（MPF），正被作为与石棉相关的癌症恶性间皮瘤（MM）的生物标志物进行研究。当血清水平保持正常时，胸腔液中的 MM 生物标志物可能会升高。本研究的目的是确定 MPF 是否也是如此，并比较间皮素的水平。在 66 名 MM 患者、39 名其他恶性肿瘤患者、37 名良性疾病患者、18 名接触石棉的健康个体和 53 名慢性肾病患者中比较了生物标志物浓度。在胸腔积液中，与对照组相比，MM 患者的 MPF 和可溶性间皮素浓度均显著升高。在区分 MM 与所有其他胸腔积液病因时，MPF（0.945±0.02）和间皮素（0.928±0.03）的曲线下面积（AUC）之间没有显著差异。MPF 和间皮素的血清浓度高度相关，诊断准确性相当，AUC 分别为 0.813±0.04 和 0.829±0.03。两种标志物的血清水平均随肾功能下降而升高。总之，MPF 在 MM 患者的胸腔积液中升高，与间皮素相似。间皮素和 MPF 在区分胸腔积液中的 MM 与其他疾病以及血清中具有相当的诊断信息。
