Department of Psychiatry, Ladoke Akintola University Teaching Hospital, Osogbo, Nigeria.
Ther Adv Psychopharmacol. 2013 Oct;3(5):275-7. doi: 10.1177/2045125313481026.
Clozapine is regarded as a second-line and in some cases last-line antipsychotic known for its common life-threatening side effects, such as agranulocytosis, constipation and cardiomyopathies, but rarely haematemesis. We report a case of severe haemetemesis in a chronic schizophrenic patient managed with clozapine. The patient was a 46-year-old male being managed for chronic schizophrenia with treatment resistance who developed sudden severe haematemesis following commencement of clozapine for 6 weeks. The patient had 1.1 l of blood transfusion. The relevant literature is reviewed. Clozapine can be associated with a life-threatening haematemesis. Psychiatrists and other medical specialists need to be alert to the fatality of clozapine-induced haematemesis in the treatment of psychiatric disorders.
氯氮平被认为是一种二线药物，在某些情况下是最后一线抗精神病药物，其常见的危及生命的副作用包括粒细胞缺乏症、便秘和心肌病，但很少出现呕血。我们报告了一例慢性精神分裂症患者服用氯氮平后出现严重呕血的病例。该患者为一名 46 岁男性，患有慢性精神分裂症，对治疗有抵抗，在开始服用氯氮平 6 周后突然出现严重呕血。患者输了 1.1 升血。回顾了相关文献。氯氮平可导致危及生命的呕血。精神科医生和其他医学专家在治疗精神疾病时需要警惕氯氮平引起的呕血的致命性。
