抗胆碱能药物对胃食管反流及相关病症的影响。

The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders.

作者信息

van Soest Eva M, Dieleman Jeanne P, Kuipers Ernst J

机构信息

Erasmus University Medical Center, Department of Gastroenterology and Hepatology, Postbus 2040, 3000 CA Rotterdam, The Netherlands.

出版信息

Expert Opin Drug Saf. 2008 Mar;7(2):173-80. doi: 10.1517/14740338.7.2.173.

DOI:10.1517/14740338.7.2.173

PMID:18324880

Abstract

The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.

摘要

食管腺癌最重要的风险因素是胃食管反流病。胃食管反流病本身就是一种常见疾病，会引发令人困扰的症状。在日常临床实践中，抗胆碱能药物被认为会通过影响食管下括约肌而增加胃食管反流的风险。在本综述中，我们讨论了关于具有抗胆碱能特性的药物使用与胃食管反流相关疾病风险之间潜在关联的现有文献。