Alper J C, Wiemann M C, Rueckl F S, McDonald C J, Calabresi P
J Am Acad Dermatol. 1985 Oct;13(4):567-77. doi: 10.1016/s0190-9622(85)70198-3.
In an effort to improve clinical response and reduce systemic toxicity, nine patients with recalcitrant psoriasis were treated with rational combinations of chemotherapeutic agents. Five patients received methotrexate by injection, 7.5 or 10 mg, followed 1 hour later by intravenous 5-fluorouracil, 170 to 562 mg/m2, on a weekly schedule. Four patients received oral triacetyl-azauridine, 2 to 4 gm daily, in combination with intravenous 5-fluorouracil, 225 to 600 mg/m2, administered every week. Three patients experienced greater than 75% clearing of disease, five patients experienced greater than 50% clearing, and only one patient failed to respond. Response rates did not differ between the two treatment groups. Adverse effects of these therapies were mild and infrequent. We conclude that 5-fluorouracil in combination with either methotrexate or triacetyl-azauridine is a relatively safe and effective alternative for the therapy of patients with severe psoriasis.
为了提高临床疗效并降低全身毒性，对9例顽固性银屑病患者采用合理的化疗药物联合方案进行治疗。5例患者接受甲氨蝶呤注射治疗，剂量为7.5或10mg，1小时后静脉注射5-氟尿嘧啶，剂量为170至562mg/m²，每周一次。4例患者每天口服2至4g三乙酰氮尿苷，同时联合静脉注射5-氟尿嘧啶，剂量为225至600mg/m²，每周给药一次。3例患者疾病清除率超过75%，5例患者清除率超过50%，只有1例患者无反应。两个治疗组的有效率无差异。这些治疗的不良反应轻微且不常见。我们得出结论，5-氟尿嘧啶联合甲氨蝶呤或三乙酰氮尿苷是治疗重度银屑病患者的一种相对安全有效的替代方案。
