Moschella S L
Int J Dermatol. 1976 Jun;15(5):373-8. doi: 10.1111/j.1365-4362.1976.tb01813.x.
The hunt for an effective, easier to administer, more acceptable therapeutic modality for extensive chronic psoriasis continues. The chemotherapy of psoriasis is reviewed in 246 patients from 1964 to 1974 treated with methotrexate, 92 patients from 1971 to 1974 with hydroxyurea, and 36 patients from 1972 to 1974 with azaribine. Currently, the available chemotherapy agents are the least palatable and desirable form of treatment. Methotrexate continues to be the most predictable, effective and least expensive. The use of photochemotherapy may prove to be more effective, less toxic, and more practical until a more specific and effective etiologically directed form of therapy becomes available.
对于广泛慢性银屑病，人们仍在寻找一种有效、易于给药且更易接受的治疗方式。回顾了1964年至1974年接受甲氨蝶呤治疗的246例银屑病患者、1971年至1974年接受羟基脲治疗的92例患者以及1972年至1974年接受阿扎立宾治疗的36例患者的银屑病化疗情况。目前，现有的化疗药物是最难以接受且不理想的治疗形式。甲氨蝶呤仍然是最可预测、最有效且最便宜的药物。在获得更具特异性和有效性的病因导向治疗形式之前，光化学疗法可能被证明更有效、毒性更小且更实用。
