Onitsuka Toshiaki
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University.
Seishin Shinkeigaku Zasshi. 2013;115(8):847-52.
It has been suggested that psychotic symptoms of schizophrenia are associated with brain dysfunction at least to some extent. This article overviewed hot topics in neurophysiological studies of patients with schizophrenia. Moreover, it focused on recent findings in electroencephalography and magnetoencephalography. First, the author introduced auditory mismatch negativities (MMN), auditory P300, face N170, and gamma band neural oscillations. Findings of MMN and P300 supported schizophrenia being characterized by brain dysfunctions, some of which occur before full symptom onset and some progress in the 1-2 years after onset. In addition, neurophysiological indices for social dysfunction may lead to new preventive approaches. Finally, neural oscillations are possible translational paradigms, since they can be recorded from animals, healthy subjects, and patients with schizophrenia. To understand the pathophysiology of schizophrenia, neurophysiological efforts are important.
有人认为，精神分裂症的精神病性症状至少在一定程度上与脑功能障碍有关。本文概述了精神分裂症患者神经生理学研究中的热点话题。此外，还重点介绍了脑电图和脑磁图的最新研究结果。首先，作者介绍了听觉失匹配负波（MMN）、听觉P300、面孔N170和伽马波段神经振荡。MMN和P300的研究结果支持精神分裂症具有脑功能障碍的特征，其中一些在症状完全出现之前就已发生，一些在发病后的1-2年内进展。此外，社会功能障碍的神经生理学指标可能会带来新的预防方法。最后，神经振荡是可能的转化范式，因为它们可以在动物、健康受试者和精神分裂症患者中记录。为了理解精神分裂症的病理生理学，神经生理学研究很重要。
