Olszynski Wojciech P, Brown Jacques P, Adachi Jonathan D, Hanley David A, Ioannidis George, Davison K Shawn
Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Department of Medicine, Laval University, Quebec City, Quebec, Canada.
J Clin Densitom. 2014 Oct-Dec;17(4):534-40. doi: 10.1016/j.jocd.2013.09.017. Epub 2013 Oct 26.
Multisite quantitative ultrasound (mQUS) machines are attractive tools for assessing fragility fracture risk as they are often portable, comparatively inexpensive, require little training for their use, and emit no ionizing radiation. The primary objective of this investigation was to generate an mQUS normative database of speed of sound (SOS, in m/s) measures from a large sample of randomly selected community-based individuals. mQUS (BeamMed Omnisense MultiSite Quantitative Ultrasound 7000 S) measurements were obtained and assessed at the distal radius, tibia, and phalanx. All analyses were made separately for men and women and for each anatomical site. Scatterplots (SOS vs age) identified 30-39 yr of age as periods of both maximal SOS and of relative stability for all 3 sites over the age span investigated (30-96 yr of age; 2948 women and 1176 men) and, thus, was used as the "reference" population. For cross-sectional comparison of trends over aging, a number of age groupings were created: 30-39, 40-49, 50-59, 60-69, 70-79, and 80+ yr. In general, there were decreases in SOS over increasing age groupings. The normative data generated can be used to compare a given patient's mQUS measurement with reference to a young, healthy population, assigning them a gender-appropriate T-score.
多部位定量超声（mQUS）设备是评估脆性骨折风险的理想工具，因为它们通常便于携带、价格相对低廉、使用时几乎无需培训，且不产生电离辐射。本研究的主要目的是从大量随机选取的社区个体样本中生成一个关于声速（SOS，单位为米/秒）测量值的mQUS标准数据库。在桡骨远端、胫骨和指骨处进行了mQUS（BeamMed Omnisense多部位定量超声7000 S型）测量并进行评估。所有分析均按性别以及每个解剖部位分别进行。散点图（SOS与年龄）显示，在所研究的年龄跨度（30 - 96岁；2948名女性和1176名男性）内，30 - 39岁是所有三个部位SOS最高且相对稳定的时期，因此被用作“参考”人群。为了对衰老过程中的趋势进行横断面比较，创建了多个年龄分组：30 - 39岁、40 - 49岁、50 - 59岁、60 - 69岁、70 - 79岁和80岁及以上。一般来说，随着年龄分组的增加，SOS会降低。所生成的标准数据可用于将给定患者的mQUS测量值与年轻健康人群进行比较，并为他们赋予适合性别的T分数。
