Oral Aydan, Esmaeilzadeh Sina, Yalıman Ayşe, Sindel Dilşad, Kürsüz Köseoğlu Pınar, Aydın Tuğba
Department of Physical Medicine and Rehabilitation, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
Turk J Phys Med Rehabil. 2019 Jul 30;65(3):203-215. doi: 10.5606/tftrd.2019.1894. eCollection 2019 Sep.
The aim of this study was to assess the ability of calcaneal and multisite quantitative ultrasound (QUS) parameters in the identification of osteoporosis in women and men.
A total of 131 women (mean age 53.7±11.9 years; range, 21 to 79 years) and 109 men (mean age 57.8±13.7 years; range, 24 to 85 years) whose bone mineral density (BMD) at the spine and proximal femur was measured between January 2010 and January 2012, using dual-energy X-ray absorptiometry (DXA) were included. Acoustic bone properties were also examined using both a calcaneal and a multisite QUS. The receiver operating characteristic analysis with the calculation of areas under the curve (AUCs) to evaluate the ability of both QUS devices for the identification of osteoporosis. We also calculated a lower and an upper threshold at a specificity of 90% and at a sensitivity of 90%, respectively, for the identification of osteoporosis along with a threshold/cut-off value with the best compromise between sensitivity and specificity.
All calcaneal QUS parameters showed significant AUCs within the range of 0.712 (for Broadband Ultrasound Attenuation [BUA]) and 0.764 (for Speed of Sound [SOS]) in women and ranging from 0.661 (for BUA) to 0.735 (for SOS) in men, while only radial SOS of the multisite QUS demonstrated a significant AUC value of 0.661 for identifying osteoporosis in women. A Quantitative Ultrasound Index T-score of -1.53 for women and -1.68 for men showed sensitivity and specificities around 70%.
Based on the results of this study, all calcaneal QUS parameters in both women and men and possibly radial SOS measurements of the multisite QUS in women may be helpful for the identification of osteoporosis.
本研究旨在评估跟骨和多部位定量超声（QUS）参数在识别女性和男性骨质疏松症方面的能力。
纳入2010年1月至2012年1月期间使用双能X线吸收法（DXA）测量了脊柱和股骨近端骨密度（BMD）的131名女性（平均年龄53.7±11.9岁；范围21至79岁）和109名男性（平均年龄57.8±13.7岁；范围24至85岁）。还使用跟骨和多部位QUS检查了声学骨特性。通过计算曲线下面积（AUC）进行受试者工作特征分析，以评估两种QUS设备识别骨质疏松症的能力。我们还分别计算了特异性为90%和敏感性为90%时用于识别骨质疏松症的下限和上限阈值，以及在敏感性和特异性之间取得最佳折衷的阈值/临界值。
所有跟骨QUS参数在女性中的AUC均显著，范围为0.712（宽带超声衰减[BUA]）至0.764（声速[SOS]），在男性中为0.661（BUA）至0.735（SOS），而多部位QUS仅桡骨SOS在女性中识别骨质疏松症的AUC值为0.661。女性的定量超声指数T值为-1.53，男性为-1.68，其敏感性和特异性约为70%。
基于本研究结果，男性和女性的所有跟骨QUS参数以及女性多部位QUS的桡骨SOS测量结果可能有助于识别骨质疏松症。
