铜催化的偕二氟烯烃化合物与 TMSCF3 通过 C-F 键断裂的反应。
Copper-catalyzed gem-difluoroolefination of diazo compounds with TMSCF3 via C-F bond cleavage.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Ling-Ling Road, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2013 Nov 20;135(46):17302-5. doi: 10.1021/ja409941r. Epub 2013 Nov 5.
PMID:24171471
Abstract
A novel Cu-catalyzed gem-difluoroolefination of diazo compounds is described. This transformation starts from readily available TMSCF3 and diazo compounds, via trifluoromethylation followed by C-F bond cleavage, to afford the desired 1,1-difluoroalkene products.
摘要
本文描述了一种新型的铜催化的重氮化合物的偕二氟烯烃化反应。该转化过程从易得的 TMSCF3 和重氮化合物开始，通过三氟甲基化和 C-F 键的断裂，得到所需的 1,1-二氟烯烃产物。
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