三氟甲基化烯丙基硅烷的光氧化还原催化反应。
Trifluoromethylation of allylsilanes under photoredox catalysis.
机构信息
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
出版信息
Org Lett. 2013 Mar 15;15(6):1250-3. doi: 10.1021/ol400184t. Epub 2013 Mar 6.
PMID:23465076
Abstract
A new catalytic method to access allylic secondary CF3 products is described. These reactions use the visible light excited Ru(bpy)3Cl2·6H2O catalyst and the Togni or Umemoto reagent as the CF3 source. The photoredox catalytic manifold delivers enantioenriched allylic trifluoromethylated products not accessible under Cu(I) catalysis.
摘要
描述了一种新的催化方法来获得烯丙基仲 CF3 产物。这些反应使用可见光激发的 Ru(bpy)3Cl2·6H2O 催化剂和 Togni 或 Umemoto 试剂作为 CF3 源。光氧化还原催化途径提供了手性富集的烯丙基三氟甲基化产物，这在 Cu(I)催化下是无法获得的。
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