David Geffen School of Medicine, University of California, Los Angeles, CA.
Am J Clin Nutr. 2013 Dec;98(6 Suppl):1651S-1659S. doi: 10.3945/ajcn.113.059345. Epub 2013 Oct 30.
The present analysis was conducted in response to inconsistent epidemiologic studies on the relation between consumption of tea and cardiovascular diseases.
We undertook a literature review of the consistency and strength of the associations between tea and cardiovascular diseases on the basis of published observational studies and meta-analyses addressing tea or tea flavonoids and cardiovascular disease risk.
We performed a search in 3 databases for meta-analyses and compared them with studies they subsumed. We performed an additional search for subsequent studies to determine whether the conclusions were consistent.
Many epidemiologic studies have been conducted and summarized in 5 meta-analyses on either tea consumption or flavonoid consumption and cardiovascular disease or the subset of stroke. Heterogeneity of effect was seen when the outcome included all cardiovascular diseases. In the case of stroke, a consistent, dose-response association with tea consumption on both incidence and mortality was noted with RRs of 0.80 (95% CI: 0.65, 0.98) for flavonoids and 0.79 (95% CI: 0.73, 0.85) for tea when high and low intakes were compared or the addition of 3 cups/d was estimated.
Thus, the strength of this evidence supports the hypothesis that tea consumption might lower the risk of stroke.
目前的分析是针对茶消费与心血管疾病之间的关系的不一致的流行病学研究而进行的。
我们对已发表的关于茶或茶类黄酮与心血管疾病风险的观察性研究和荟萃分析进行了文献回顾，以评估茶与心血管疾病之间关联的一致性和强度。
我们在 3 个数据库中进行了荟萃分析的检索，并将其与所包含的研究进行了比较。我们还进行了后续研究的额外检索，以确定结论是否一致。
已经进行了许多流行病学研究，并在 5 项关于茶消费或类黄酮消费与心血管疾病或中风亚组的荟萃分析中进行了总结。当包括所有心血管疾病的结果时，观察到效果存在异质性。在中风的情况下，与茶消费相关的一致性、剂量反应关联在发病率和死亡率上都得到了观察，高摄入量和低摄入量相比，类黄酮的 RR 为 0.80（95% CI：0.65，0.98），茶的 RR 为 0.79（95% CI：0.73，0.85），或估计每天增加 3 杯。
因此，这一证据的强度支持了这样一种假设，即茶的消费可能降低中风的风险。
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