Institute of Respiratory Diseases, Xiamen Medical College, Xiamen, Fujian Province, 361023, P.R. China.
Fujian Provincial Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Xiamen, Fujian Province, 361023, P.R. China.
BMC Pulm Med. 2023 Nov 22;23(1):461. doi: 10.1186/s12890-023-02762-4.
Numerous studies have reported the association between tea intake and lung diseases. However, the probable relationship between tea consumption on lung diseases still remain controversial and it is unclear whether these findings are due to reverse causality or confounding factor.
In order to systematically investigate the causal connection between tea intake on respiratory system disorders, we employed a two-sample Mendelian randomized (MR) study. Genetic instruments for tea intake were identified from a genome-wide association study (GWAS) involving 447,385 individuals. Data on lung diseases were collected from a variety of publicly available genome-wide association studies. The main method used for MR analysis is the inverse variance weighting (IVW) method. To ensure the accuracy of the findings, further sensitivity analysis was conducted.
The IVW method in our MR analysis revealed no evidence to support a causal relationship between tea intake and lung diseases (IPF: OR = 0.997, 95% CI = 0.994-1.000, p = 0.065; Lung cancer: OR = 1.003, 95% CI = 0.998-1.008, P = 0.261; COPD: OR = 1.001, 95% CI = 0.993-1.006, p = 0.552; acute bronchitis: OR = 0.919, 95% CI = 0.536-1.576, p = 0.759; tuberculosis: OR = 1.002, 95% CI = 0.998-1.008, p = 0.301; pneumonia: OR = 0.789, 95% CI = 0.583-1.068, p = 0.125). The reliability of the results was further demonstrated by four additional MR analysis techniques and additional sensitivity testing.
We found no evidence of a link between tea intake on lung diseases in our MR results based on genetic information.
大量研究报告了饮茶与肺部疾病之间的关联。然而，饮茶与肺部疾病之间的可能关系仍存在争议，目前尚不清楚这些发现是由于反向因果关系还是混杂因素所致。
为了系统地研究饮茶与呼吸系统疾病之间的因果关系，我们采用了两样本孟德尔随机化（MR）研究。饮茶的遗传工具是从一项涉及 447385 人的全基因组关联研究（GWAS）中确定的。肺部疾病的数据来自各种公开可用的全基因组关联研究。MR 分析主要采用逆方差加权（IVW）法。为了确保结果的准确性，还进行了进一步的敏感性分析。
我们的 MR 分析中的 IVW 方法没有证据表明饮茶与肺部疾病之间存在因果关系（特发性肺纤维化：OR=0.997，95%CI=0.994-1.000，p=0.065；肺癌：OR=1.003，95%CI=0.998-1.008，P=0.261；COPD：OR=1.001，95%CI=0.993-1.006，p=0.552；急性支气管炎：OR=0.919，95%CI=0.536-1.576，p=0.759；肺结核：OR=1.002，95%CI=0.998-1.008，p=0.301；肺炎：OR=0.789，95%CI=0.583-1.068，p=0.125）。我们还通过四种额外的 MR 分析技术和额外的敏感性测试进一步验证了结果的可靠性。
根据遗传信息，我们在 MR 结果中没有发现饮茶与肺部疾病之间存在关联的证据。
