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Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.低剂量的苯环利定可选择性阻断大鼠脑中一种突触前电压调节性钾通道。
Proc Natl Acad Sci U S A. 1986 Jan;83(1):189-92. doi: 10.1073/pnas.83.1.189.
2
Phencyclidine in nanomolar concentrations binds to synaptosomes and blocks certain potassium channels.纳摩尔浓度的苯环利定与突触体结合并阻断某些钾通道。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3855-9. doi: 10.1073/pnas.80.12.3855.
3
m-Azido-phencyclidine covalently labels the rat brain PCP receptor, a putative K channel.间叠氮苯环利定可共价标记大鼠脑内的苯环利定受体，一种假定的钾通道。
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Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.拟精神病性西格玛配体、右吗啉醇和苯环利定可阻断大鼠脑中相同的突触前钾通道。
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Tityustoxin K alpha blocks voltage-gated noninactivating K+ channels and unblocks inactivating K+ channels blocked by alpha-dendrotoxin in synaptosomes.泰氏蝎毒素Kα可阻断电压门控性非失活钾通道，并使在突触体中被α-树眼镜蛇毒素阻断的失活钾通道去阻断。
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Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain.拟精神病性西格玛配体、右吗啉醇和苯环利定可阻断大鼠脑中相同的突触前钾通道。
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9
Phencyclidine binds to blood platelets with high affinity and specifically inhibits their activation by adrenaline.苯环利定与血小板具有高亲和力结合，并特异性抑制肾上腺素对其的激活作用。
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本文引用的文献

1
Phencyclidine (PCP) intoxication: diagnosis in stages and algorithms of treatment.苯环己哌啶（PCP）中毒：分期诊断与治疗算法
Clin Toxicol. 1980 Jun;16(4):509-29. doi: 10.3109/15563658008989980.
2
Evaluation of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat.
J Pharmacol Exp Ther. 1981 Mar;216(3):543-51.
3
Effects of phencyclidine on cardiac action potential: pH dependence and structure-activity relationships.苯环利定对心脏动作电位的影响：pH依赖性及构效关系。
Eur J Pharmacol. 1983 Apr 8;88(4):283-90. doi: 10.1016/0014-2999(83)90578-2.
4
The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.分离麻醉药氯胺酮和苯环己哌啶可选择性降低N-甲基天冬氨酸对中枢哺乳动物神经元的兴奋作用。
Br J Pharmacol. 1983 Jun;79(2):565-75. doi: 10.1111/j.1476-5381.1983.tb11031.x.
5
Phencyclidine in nanomolar concentrations binds to synaptosomes and blocks certain potassium channels.纳摩尔浓度的苯环利定与突触体结合并阻断某些钾通道。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3855-9. doi: 10.1073/pnas.80.12.3855.
6
The behavioral effects of phencyclidines may be due to their blockade of potassium channels.苯环利定的行为效应可能归因于其对钾通道的阻断作用。
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7792-6. doi: 10.1073/pnas.78.12.7792.
7
Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.海兔中突触前易化和行为敏感化背后的钙电流调制机制。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6912-6. doi: 10.1073/pnas.77.11.6912.
8
Poisoning with 4-aminopyridine: report of three cases.
Clin Toxicol. 1980 Jun;16(4):487-97. doi: 10.3109/15563658008989978.
9
Dopamine receptors, neuroleptics, and schizophrenia.多巴胺受体、抗精神病药物与精神分裂症
Am J Psychiatry. 1981 Apr;138(4):460-4. doi: 10.1176/ajp.138.4.460.
10
An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?大鼠大脑皮层中N-甲基-D-天冬氨酸受体介导的突触：氯胺酮的作用位点？
Nature. 1985;313(6002):479-81. doi: 10.1038/313479a0.

低剂量的苯环利定可选择性阻断大鼠脑中一种突触前电压调节性钾通道。

Phencyclidine in low doses selectively blocks a presynaptic voltage-regulated potassium channel in rat brain.

作者信息

Bartschat D K, Blaustein M P

出版信息

Proc Natl Acad Sci U S A. 1986 Jan;83(1):189-92. doi: 10.1073/pnas.83.1.189.

DOI:10.1073/pnas.83.1.189
PMID:2417237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC322817/
Abstract

Phencylidine (PCP) is a major drug of abuse in the United States. It produces a toxic confusional psychosis in man. We show here that nanomolar to micromolar concentrations of PCP and behaviorally active congeners selectively block voltage-regulated noninactivating (or very slowly inactivating) presynaptic K channels in the brain. The rank order of potency for blockage of these K channels parallels both the relative ability of these agents to produce characteristic behavioral deficits in rats and their ability to displace [3H]PCP from its high-affinity binding sites in brain. In view of the enhanced voltage-gated Ca influx that would be expected to accompany blockage of presynaptic K channels, this mechanism could explain the excessive neurotransmitter release that is characteristic of PCP intoxication.

摘要

苯环利定（PCP）是美国一种主要的滥用药物。它会在人类中引发中毒性混淆性精神病。我们在此表明，纳摩尔至微摩尔浓度的PCP及其具有行为活性的同系物能选择性地阻断大脑中电压调节性非失活（或非常缓慢失活）的突触前钾通道。这些钾通道阻断效力的顺序与这些药物在大鼠中产生特征性行为缺陷的相对能力以及它们从大脑中高亲和力结合位点置换[3H]PCP的能力均平行。鉴于预计突触前钾通道的阻断会伴随电压门控性钙内流增加，这种机制可以解释PCP中毒所特有的神经递质过度释放现象。