Contreras P C, Monahan J B, Lanthorn T H, Pullan L M, DiMaggio D A, Handelmann G E, Gray N M, O'Donohue T L
Central Nervous Systems Research, G.D. Searle & Co., Chesterfield, MO 63198.
Mol Neurobiol. 1987 Fall;1(3):191-211. doi: 10.1007/BF02936608.
Phenycyclidine (PCP) produces many profound effects in the central nervous system. PCP has numerous behavioral and neurochemical effects such as inhibiting the uptake and facilitating the release of dopamine, serotonin, and norepinephrine. PCP also interacts with sigma, mu opioid, muscarinic, and nicotinic receptors. However, the psychotomimetic effects induced by PCP are believed to be mediated by specific PCP receptors, where PCP binds with greater potency than sigma compounds. Electrophysiological, behavioral, and neuro-chemical evidence strongly suggests that at least some of the many PCP actions result from antagonism of excitatory amino acid-induced responses via PCP receptors. The recent isolation and partial characterization of the alpha and beta endopsychosins and the identification of other endogenous ligands for the PCP and sigma receptors, is another promising area of research in the elucidation of the physiological role of an endogenous PCP and sigma system.
苯环利定（PCP）在中枢神经系统中产生许多深远影响。PCP具有多种行为和神经化学作用，例如抑制多巴胺、5-羟色胺和去甲肾上腺素的摄取并促进其释放。PCP还与σ、μ阿片样物质、毒蕈碱和烟碱受体相互作用。然而，PCP诱导的拟精神病效应被认为是由特定的PCP受体介导的，在这些受体上PCP的结合效力高于σ化合物。电生理、行为和神经化学证据有力地表明，PCP的许多作用中至少有一些是通过PCP受体拮抗兴奋性氨基酸诱导的反应所致。最近α和β内精神肽的分离及部分特性鉴定以及PCP和σ受体其他内源性配体的鉴定，是阐明内源性PCP和σ系统生理作用的另一个有前景的研究领域。
