Rodgers R J, Randall J I
Pharmacol Biochem Behav. 1985 Nov;23(5):883-7. doi: 10.1016/0091-3057(85)90087-5.
It has recently been reported that male mice exhibit pronounced analgesia in response to attack from aggressive conspecifics. Although several studies indicate that this reaction can be blocked by opiate antagonist pretreatment, unequivocal evidence of opioid involvement is very much more limited. In the present study, the phenomenon of conflict analgesia has been studied in male DBA/2 intruder mice following exposure to a criterion level of attack from aggressive BKW residents. Our findings indicate that this analgesia is blocked and reversed by naloxone unaltered by methyl naloxone, except at high doses (75 mg/kg) and fully cross-tolerant with morphine. This profile confirms and extends earlier findings with B6AF1 mice, indicating that the opioid mediation of this biologically-relevant form of environmental analgesia is not strain specific.
最近有报道称，雄性小鼠在受到同种好斗个体攻击时会表现出明显的镇痛作用。尽管多项研究表明，这种反应可被阿片类拮抗剂预处理所阻断，但阿片类物质参与其中的确切证据却非常有限。在本研究中，我们对雄性DBA/2入侵小鼠在遭受来自好斗的BKW定居者的标准水平攻击后出现的冲突镇痛现象进行了研究。我们的研究结果表明，这种镇痛作用可被纳洛酮阻断并逆转，而甲基纳洛酮则无此作用，除非使用高剂量（75毫克/千克），且与吗啡完全交叉耐受。这一情况证实并扩展了早期对B6AF1小鼠的研究结果，表明这种与生物学相关的环境性镇痛作用的阿片类介导并非品系特异性的。
