Fachbereich Chemie, Universität Konstanz, Konstanz, Germany.
J Membr Biol. 1970 Dec;3(1):291-312. doi: 10.1007/BF01868021.
As a model for the resting axon membrane, we propose the ionic psn-junction. Its electrical characteristics can be determined in close analogy to the corresponding electronic semiconductor junction. Using the "semianalytic approximation", we calculated the electrical capacity and the ionic currents. In contrast to the abrupt pn-junction, the electrical capacity of the psn-junction turns out to be practically voltage-independent, as it is observed for the squid axon membrane. The passive ionic fluxes for K(+), Na(+) and Cl(-), as the main contributions to the total charge flux, are calculated and compared with literature data on the ion fluxes through the resting squid axon membrane as measured by use of radioactive tracers. From this comparison, the ionic permeabilities can be evaluated and used to compute the resting membrane conductivity, which is found to be close to the experimental value. Further evidence in favor of the proposed asymmetrical membrane structure and possible ways of its test by the methods of protein chemistry are discussed.
我们提出离子 psn 结作为静息轴突膜的模型。其电特性可以通过与相应的电子半导体结的紧密类比来确定。使用“半解析近似”，我们计算了电容量和离子电流。与突然的 pn 结不同，psn 结的电容量实际上与电压无关，这与鱿鱼轴突膜的观察结果一致。作为总电荷通量的主要贡献，计算了 K(+)、Na(+)和 Cl(-)的被动离子通量，并与使用放射性示踪剂测量的静止鱿鱼轴突膜中离子通量的文献数据进行了比较。从这种比较中，可以评估离子渗透率，并用于计算静息膜电导率，发现其接近实验值。进一步讨论了支持所提出的不对称膜结构的证据，以及通过蛋白质化学方法对其进行测试的可能方法。
