用葡萄糖偶联的乳酸脱氢酶抑制剂双重靶向瓦博格效应。
Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.
机构信息
Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801 (USA).
出版信息
Chembiochem. 2013 Nov 25;14(17):2263-7. doi: 10.1002/cbic.201300562. Epub 2013 Oct 31.
Abstract
Effective glucose diet: We report the development and activity of glucose-conjugated LDH-A inhibitors designed for dual targeting of the Warburg effect (elevated glucose uptake and glycolysis) in cancer cells. Glycoconjugation could be applied to inhibitors of many enzymes involved in glycolysis or tumor metabolism.
摘要
有效葡萄糖饮食
我们报告了葡萄糖缀合的 LDH-A 抑制剂的开发和活性，该抑制剂旨在双重靶向癌细胞中的瓦博格效应（葡萄糖摄取和糖酵解增加）。糖缀合可以应用于许多参与糖酵解或肿瘤代谢的酶的抑制剂。
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