Qiao Yifan, Liu Yijia, Ran Ran, Zhou Yan, Gong Jin, Liu Lijuan, Zhang Yusi, Wang Hui, Fan Yuan, Fan Yihan, Nan Gengrui, Zhang Peng, Yang Jin
Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Precision Medicine Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Cancer Metastasis Rev. 2025 Apr 28;44(2):48. doi: 10.1007/s10555-025-10264-4.
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy substrate, metabolite, and signaling molecule in cancer. The reprogramming of glucose metabolism and the Warburg effect in breast cancer results in extensive lactate production and accumulation, making it likely that lactylation in tumor tissue is also abnormal. This review summarizes evidence on lactylation derived from studies of lactate metabolism and disease, highlighting the role of lactate in the tumor microenvironment of breast cancer and detailing the levels of lactylation and cancer-promoting mechanisms across various tumors. The roles of lactate and lactylation, along with potential intervention mechanisms, are presented and discussed, offering valuable insights for future research on the role of lactylation in tumors.
作为糖酵解的终产物，乳酸除了作为癌症中的能量底物、代谢物和信号分子外，还充当蛋白质乳酰化的调节剂。乳腺癌中葡萄糖代谢的重编程和瓦伯格效应导致大量乳酸生成和积累，这使得肿瘤组织中的乳酰化也可能异常。本综述总结了来自乳酸代谢和疾病研究的关于乳酰化的证据，强调了乳酸在乳腺癌肿瘤微环境中的作用，并详细阐述了各种肿瘤中乳酰化水平及促癌机制。文中介绍并讨论了乳酸和乳酰化的作用以及潜在的干预机制，为未来关于乳酰化在肿瘤中作用的研究提供了有价值的见解。
