多发性硬化症、肌萎缩侧索硬化症及正常对照中循环免疫复合物中DNA和RNA的特征分析

Characterization of DNA and RNA in circulating immunocomplexes in multiple sclerosis, amyotrophic lateral sclerosis and normal controls.

作者信息

Unger M, Wettergren A, Clausen J

出版信息

Acta Neurol Scand. 1985 Oct;72(4):392-6. doi: 10.1111/j.1600-0404.1985.tb00889.x.

DOI:10.1111/j.1600-0404.1985.tb00889.x

Abstract

The total levels of DNA and RNA in serum immunocomplexes from multiple sclerosis (MS) patients and healthy control persons were compared. Furthermore, the levels of single-stranded DNA (ss DNA) and double-stranded DNA (ds DNA) in serum immunocomplexes from MS patients, amyotrophic lateral sclerosis (ALS) patients and controls were studied. The mean values of DNA and RNA were found to be elevated (P less than 0.01) in MS compared to the control means. Furthermore, the RNA/DNA ratio and the ratio ss DNA/ds DNA were decreased in MS. In contrast the ss:ds DNA ratio in ALS was increased. In ALS, however, the sum of ss DNA and ds DNA was lower (P less than 0.05) than the control mean value.

摘要

比较了多发性硬化症（MS）患者和健康对照者血清免疫复合物中DNA和RNA的总水平。此外，还研究了MS患者、肌萎缩侧索硬化症（ALS）患者和对照者血清免疫复合物中单链DNA（ss DNA）和双链DNA（ds DNA）的水平。发现与对照平均值相比，MS患者的DNA和RNA平均值升高（P小于0.01）。此外，MS患者的RNA/DNA比值和ss DNA/ds DNA比值降低。相比之下，ALS患者的ss:ds DNA比值升高。然而，在ALS患者中，ss DNA和ds DNA的总和低于对照平均值（P小于0.05）。