Oates P S, Morgan R G, Light A M
Am J Physiol. 1986 Jan;250(1 Pt 1):G9-14. doi: 10.1152/ajpgi.1986.250.1.G9.
Involution of the enlarged pancreas was studied in rats changed from a diet of raw soya flour (RSF) to a normal diet of cubes. After feeding RSF for 4 or 12 wk pancreatic weight, DNA, RNA, and protein were all significantly greater than in control animals fed cubes continuously. When these animals were changed to a cube diet, pancreatic DNA and RNA returned to control values within 48 h, while pancreatic weight and protein reverted to control values within 7 days of the change in diet. The morphological changes seen in the pancreas during involution indicate that cell death occurred by the process of apoptosis. Increased cell death during involution was seen as a rapid increase in the incidence of apoptotic bodies (AB) located in the cytoplasm of intact acinar cells and macrophages. These AB's contained condensed fragments of cytoplasm, nuclear, or a combination of these remnants, which were derived from the acinar cell. The increase in apoptosis after withdrawal of the RSF diet was probably in response to the withdrawal of the trophic influence, cholecystokinin.
对从食用生大豆粉（RSF）饮食改为正常块状食物饮食的大鼠的胰腺肿大消退情况进行了研究。在喂食RSF 4周或12周后，胰腺重量、DNA、RNA和蛋白质均显著高于持续喂食块状食物的对照动物。当这些动物改为块状食物饮食时，胰腺DNA和RNA在48小时内恢复到对照值，而胰腺重量和蛋白质在饮食改变后7天内恢复到对照值。胰腺在消退过程中出现的形态学变化表明细胞死亡是通过凋亡过程发生的。在消退过程中细胞死亡增加表现为完整腺泡细胞和巨噬细胞胞质中凋亡小体（AB）的发生率迅速增加。这些AB包含来自腺泡细胞的细胞质、细胞核或这些残余物组合的浓缩片段。停止RSF饮食后凋亡增加可能是对营养影响物质胆囊收缩素停止作用的反应。
