Oates P S, Morgan R G
Department of Human Biology, School of Community Health, Curtin University of Technology, Bentley, Australia.
Am J Physiol. 1988 Nov;255(5 Pt 1):G670-5. doi: 10.1152/ajpgi.1988.255.5.G670.
Pancreatic growth was studied after partial resection of the normal-sized pancreas in rats fed heated soya flour (HSF) or the enlarged gland in rats fed raw soya flour (RSF). Resection involved the removal of the splenic and gastric segments and in both the normal and enlarged gland this represents a loss of approximately 55% of total pancreatic mass. After partial resection animals were either continued on these preresected diets or changed to the alternative diets. For at least the first 8 days after resection, in all conditions studied, there was a significant increase in DNA synthesis in the pancreas, involving both parenchymal and nonparenchymal cells as shown by autoradiography. The increased cell turnover was not associated with any increase in total DNA content of the gland, indicating that the increase paralleled cell loss in response to injury caused by the surgery. By 160 days after resection of the normal pancreas, RSF feeding caused both hypertrophy and hyperplasia of the remnant, but after partial resection of the enlarged gland, growth was limited to hypertrophy. These results suggest that the pancreas has a limited capacity for additional growth after that initially caused by RSF.
在喂食加热大豆粉（HSF）的大鼠中，对正常大小的胰腺进行部分切除后研究胰腺生长情况；在喂食生大豆粉（RSF）的大鼠中，对增大的胰腺进行部分切除后研究胰腺生长情况。切除包括脾段和胃段的切除，在正常和增大的胰腺中，这都意味着胰腺总质量损失约55%。部分切除后，动物要么继续食用这些切除前的饮食，要么改为另一种饮食。在切除后的至少前8天，在所研究的所有条件下，胰腺中的DNA合成显著增加，放射自显影显示实质细胞和非实质细胞均参与其中。细胞更新增加与腺体总DNA含量的任何增加均无关，这表明这种增加与手术造成的损伤导致的细胞损失平行。正常胰腺切除160天后，喂食RSF导致残余胰腺肥大和增生，但增大的胰腺部分切除后，生长仅限于肥大。这些结果表明，胰腺在最初由RSF引起的生长之后，额外生长的能力有限。
