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干扰素调节因子8（IRF8）在癌症免疫监视中的双重作用。

The dual role of IRF8 in cancer immunosurveillance.

作者信息

Schiavoni Giovanna, Gabriele Lucia, Mattei Fabrizio

机构信息

Department of Hematology, Oncology and Molecular Medicine; Istituto Superiore di Sanità; Rome, Italy.

出版信息

Oncoimmunology. 2013 Aug 1;2(8):e25476. doi: 10.4161/onci.25476. Epub 2013 Jul 1.

DOI:10.4161/onci.25476
PMID:24175153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3810266/
Abstract

For a long time, the transcription factor interferon-regulatory factor 8 (IRF8) has been recognized as a masterpiece for the development of myeloid cells, and its role as a central regulator of immune responses has now been clarified. IRF8 is also critical for tumor progression, suggesting its fundamental relevance in multiple aspects of cancer immunosurveillance.

摘要

长期以来，转录因子干扰素调节因子8（IRF8）一直被认为是髓系细胞发育的关键因子，如今其作为免疫反应核心调节因子的作用已得到阐明。IRF8对肿瘤进展也至关重要，这表明它在癌症免疫监视的多个方面具有根本相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b5/3810266/844e80ab676a/onci-2-e25476-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b5/3810266/844e80ab676a/onci-2-e25476-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e3b5/3810266/844e80ab676a/onci-2-e25476-g1.jpg

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本文引用的文献

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J Biol Chem. 2013 Jun 28;288(26):19103-15. doi: 10.1074/jbc.M112.434530. Epub 2013 May 15.
2
The tumor microenvironment: a pitch for multiple players.肿瘤微环境：多方参与的舞台。
Front Oncol. 2013 Apr 17;3:90. doi: 10.3389/fonc.2013.00090. eCollection 2013.
3
IRF-8 controls melanoma progression by regulating the cross talk between cancer and immune cells within the tumor microenvironment.
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Genes (Basel). 2020 Apr 17;11(4):435. doi: 10.3390/genes11040435.
4
Cancer-driven dynamics of immune cells in a microfluidic environment.微流控环境中癌症驱动的免疫细胞动态变化
Sci Rep. 2014 Oct 16;4:6639. doi: 10.1038/srep06639.
IRF-8 通过调控肿瘤微环境中肿瘤细胞与免疫细胞之间的串扰来控制黑色素瘤的进展。
Neoplasia. 2012 Dec;14(12):1223-35. doi: 10.1593/neo.121444.
4
Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment.肿瘤细胞与免疫细胞的串扰：在微流控环境中探索复杂动态。
Lab Chip. 2013 Jan 21;13(2):229-39. doi: 10.1039/c2lc40887b. Epub 2012 Oct 30.
5
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6
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7
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