Mattoscio Domenico, Segré Chiara V, Chiocca Susanna
Domenico Mattoscio, Chiara V Segré, Susanna Chiocca, Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
World J Virol. 2013 May 12;2(2):79-90. doi: 10.5501/wjv.v2.i2.79.
Small ubiquitin-like modifier (SUMO)ylation is a key post-translational modification mechanism that controls the function of a plethora of proteins and biological processes. Given its central regulatory role, it is not surprising that it is widely exploited by viruses. A number of viral proteins are known to modify and/or be modified by the SUMOylation system to exert their function, to create a cellular environment more favorable for virus survival and propagation, and to prevent host antiviral responses. Since the SUMO pathway is a multi-step cascade, viral proteins engage with it at many levels, to advance and favor each stage of a typical infection cycle: replication, viral assembly and immune evasion. Here we review the current knowledge on the interplay between the host SUMO system and viral lifecycle.
小泛素样修饰物（SUMO）化是一种关键的翻译后修饰机制，可控制众多蛋白质的功能及生物过程。鉴于其核心调控作用，病毒广泛利用这一机制也就不足为奇了。已知许多病毒蛋白会被SUMO化系统修饰和/或对该系统进行修饰，以发挥其功能、营造更有利于病毒存活和传播的细胞环境，并阻止宿主的抗病毒反应。由于SUMO途径是一个多步骤级联反应，病毒蛋白在多个层面与之相互作用，以推进并促进典型感染周期的各个阶段：复制、病毒组装和免疫逃逸。在此，我们综述了关于宿主SUMO系统与病毒生命周期之间相互作用的现有知识。
