Aydogdu Ozgu
Ozgu Aydogdu, Department of Urology, Bornova Turkan Ozilhan State Hospital, Bornova, Izmir, Turkey.
World J Nephrol. 2012 Feb 6;1(1):12-5. doi: 10.5527/wjn.v1.i1.12.
The prevalence of urolithiasis is increasing in parallel with the escalating rate of obesity worldwide. It has previously been speculated that obesity is a potential risk factor for urinary stone disease. The possibility that common biochemical mechanisms underlie both obesity and urolithiasis is remarkable. Better understanding of possible common mechanisms of these diseases could potentially lead to a better management of urinary stone prevention. The prevention of urinary stone formation gives clinicians an acceptable reason to encourage lifestyle modification and weight loss through a regular diet. In this review, the association of obesity with urinary stone disease, possible common biochemical mechanisms, effects of dietary habits and weight loss on stone formation, as well as difficulties in surgical management of obese individuals with urolithiasis are discussed.
全球范围内，尿石症的患病率随着肥胖率的不断上升而增加。此前曾推测肥胖是尿路结石疾病的一个潜在风险因素。肥胖症和尿石症背后存在共同生化机制的可能性值得关注。更好地理解这些疾病可能存在的共同机制，有望改善尿路结石的预防管理。预防尿路结石形成，为临床医生提供了一个合理依据，鼓励通过规律饮食来改变生活方式并减轻体重。在这篇综述中，将讨论肥胖与尿路结石疾病的关联、可能的共同生化机制、饮食习惯和体重减轻对结石形成的影响，以及肥胖尿石症患者手术治疗中存在的困难。
