使用炔醇作为潜在二烯或亲二烯体的催化级联氢烷氧基化/异构化/[4+2]环加成反应。
Catalytic cascade hydroalkoxylation/isomerization/ [4 + 2] cycloaddition using enyne alcohols as latent dienes or dienophiles.
出版信息
Org Biomol Chem. 2013 Oct 21;11(39):6707-12. doi: 10.1039/c3ob41611a.
PMID:24175323
Abstract
Enyne alcohols can react as precursors of either dienes or dienophiles with different substrates after hydroxylation and isomerization by gold catalysis. As such, oxa-bridged tricyclo[5.2.2.02,6]-undec-8-ene-3,5-dione derivatives have been obtained by the Diels–Alder reaction and tetrahydro-1H-furo[3,4-c]pyran derivatives could be accessed by the hetero-Diels–Alder cycloaddition.
摘要
烯醇醚可通过金催化的羟化和异构化反应，作为二烯或亲二烯体的前体与不同的底物反应。例如，通过 Diels-Alder 反应得到了氧杂桥连三环[5.2.2.02,6]-十一碳-8-烯-3,5-二酮衍生物，通过杂 Diels-Alder 环加成反应可以得到四氢-1H-呋喃并[3,4-c]吡喃衍生物。
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