Du Yang, Han Li-Yuan, Li Dan-Dan, Liu Hui, Gao Yan-Hui, Sun Dian-Jun
Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, Education Bureau of Hei Long Jiang Province and Ministry of Health, Harbin, China E-mail :
Asian Pac J Cancer Prev. 2013;14(9):5483-7. doi: 10.7314/apjcp.2013.14.9.5483.
Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory.
We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively.
No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians.
Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.
XRCC1基因的Arg399Gln、Arg194Trp和Arg280His多态性与分化型甲状腺癌（DTC）风险之间的关联已得到广泛研究，但结果相互矛盾。
我们在本研究中使用STATA 11.0软件进行了一项荟萃分析，以阐明任何关联。电子文献数据库和相关文章的参考文献列表分别显示了关于Arg399Gln、Arg194Trp和Arg280His多态性的10项、6项和6项已发表研究。
在总体和亚组荟萃分析的所有遗传模型中，未观察到Arg399Gln与DTC风险之间存在显著关联，而Arg194Trp多态性的Trp/Trp与Arg/Arg以及隐性模型与DTC易感性相关，并且Arg280His多态性的显性模型在白种人中导致DTC易感性增加。
我们的荟萃分析表明，XRCC1 Arg194Trp可能是DTC发生的一个风险因素。
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