Wu Wei, Liu Lu, Yin Zhihua, Guan Peng, Li Xuelian, Zhou Baosen
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China ; Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province, Shenyang, China.
Department of Preventive Dentistry, School of Stomatology, China Medical University, Shenyang, China.
PLoS One. 2014 Jan 30;9(1):e86798. doi: 10.1371/journal.pone.0086798. eCollection 2014.
Previous studies on the association of X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg399Gln, and Arg280His polymorphisms with head and neck cancer (HNC) have produced inconsistent results. The aim of the present study was to evaluate the effects of these three polymorphic variants on HNC risk.
The PubMed and EMBASE databases were searched for genetic association studies on the XRCC1 Arg194Trp, Arg399Gln, and Arg280His polymorphisms and HNC risk. (The most recent search was conducted on 20 August, 2013.) Twenty-six studies were identified and meta-analysis was performed to evaluate the association between the polymorphism and HNC by calculating combined odds ratios and 95% confidence intervals.
No significant association was found under the allelic, homozygous, heterozygote, and dominant genetic models in the overall comparison. Further, no significant association between the XRCC1 Arg399Gln and Arg280His polymorphisms and HNC risk was detected under the four genetic models in subgroup analyses based on ethnicity, cancer site, and whether or not the studies had been adjusted for cigarette smoking and alcohol. However, in stratified analyses based on cancer site, a significant association was found between the XRCC1 Arg194Trp polymorphism and oral cancer under the allelic, heterozygote, and dominant models. The XRCC1 Arg194Trp polymorphism was significantly associated with HNC risk in studies that were adjusted for smoking and alcohol under the homozygous and heterozygote models.
The meta-analysis results suggest that the XRCC1 Arg399Gln and Arg280His polymorphisms are probably not associated with the risk of HNC, but the XRCC1 Arg194Trp polymorphism was associated with increased risk of HNC in the subgroup analysis of studies adjusted for smoking and alcohol and with increased risk of oral cancer in the stratified analyses based on cancer site. Further studies with larger samples are needed to confirm these findings.
先前关于X射线修复交叉互补基因1（XRCC1）的精氨酸194色氨酸（Arg194Trp）、精氨酸399谷氨酰胺（Arg399Gln）和精氨酸280组氨酸（Arg280His）多态性与头颈癌（HNC）相关性的研究结果并不一致。本研究旨在评估这三种多态性变异对HNC风险的影响。
检索PubMed和EMBASE数据库中关于XRCC1 Arg194Trp、Arg399Gln和Arg280His多态性与HNC风险的基因关联研究。（最近一次检索于2013年8月20日进行。）共鉴定出26项研究，并通过计算合并比值比和95%置信区间进行荟萃分析，以评估该多态性与HNC之间的关联。
在总体比较中，等位基因、纯合子、杂合子和显性遗传模型下均未发现显著关联。此外，在基于种族、癌症部位以及研究是否对吸烟和饮酒进行校正的亚组分析中，在四种遗传模型下均未检测到XRCC1 Arg399Gln和Arg280His多态性与HNC风险之间存在显著关联。然而，在基于癌症部位的分层分析中，在等位基因、杂合子和显性模型下，发现XRCC1 Arg194Trp多态性与口腔癌之间存在显著关联。在对吸烟和饮酒进行校正的研究中，在纯合子和杂合子模型下XRCC1 Arg194Trp多态性与HNC风险显著相关。
荟萃分析结果表明，XRCC1 Arg399Gln和Arg280His多态性可能与HNC风险无关，但在对吸烟和饮酒进行校正的研究亚组分析中，XRCC1 Arg194Trp多态性与HNC风险增加相关，且在基于癌症部位的分层分析中与口腔癌风险增加相关。需要进一步开展更大样本量的研究来证实这些发现。
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