Fisher D E, Reeves W H, Wisniewolski R, Lahita R G, Chiorazzi N
Arthritis Rheum. 1985 Dec;28(12):1348-55. doi: 10.1002/art.1780281206.
The Sm and RNP autoantibodies, found in the sera of many patients who have connective tissue diseases, recognize determinants on small nuclear ribonucleoprotein particles (snRNP). Numerous techniques have been used to distinguish between the subsets of snRNP proteins recognized by these two antibody systems. Using protein and snRNP immunoprecipitation, as well as a competitive enzyme-linked immunosorbent assay, antibodies in the sera of Sm patients have been observed to include variable quantities of RNP-like reactivity. To analyze changes in these autoantibodies, 2 patients with anti-Sm antibodies were followed temporally. The autoantibodies in the sera of both patients underwent shifts from predominant Sm reactivity to predominant RNP reactivity. In 1 patient the shift occurred gradually over several years, while in the other the shift occurred within 8 weeks.
在许多患有结缔组织疾病的患者血清中发现的Sm和RNP自身抗体，可识别小核核糖核蛋白颗粒（snRNP）上的决定簇。已经使用了许多技术来区分这两种抗体系统所识别的snRNP蛋白亚群。通过蛋白质和snRNP免疫沉淀以及竞争性酶联免疫吸附测定，已观察到Sm患者血清中的抗体包含可变数量的RNP样反应性。为了分析这些自身抗体的变化，对2名抗Sm抗体患者进行了随访。两名患者血清中的自身抗体均从主要的Sm反应性转变为主要的RNP反应性。在1名患者中，这种转变在几年内逐渐发生，而在另一名患者中，转变在8周内发生。
