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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.
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Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy.
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Ablation of insulin receptor substrates 1 and 2 suppresses -driven lung tumorigenesis.
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2.
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IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.
J Neurochem. 2008 Nov;107(4):907-17. doi: 10.1111/j.1471-4159.2008.05631.x. Epub 2008 Sep 18.

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Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate.
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Control of NAD homeostasis by autophagic flux modulates mitochondrial and cardiac function.
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Protective Factors and the Pathogenesis of Complications in Diabetes.
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Extracellular matrix remodelling in obesity and metabolic disorders.
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Autophagy, innate immunity, and cardiac disease.
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Insulin signaling is critical for sinoatrial node maintenance and function.
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Mitochondrial Quality Control Mechanisms during Diabetic Cardiomyopathy.
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Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity.
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Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.
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Animal Models of Dysregulated Cardiac Metabolism.
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本文引用的文献

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Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
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Guidelines for the use and interpretation of assays for monitoring autophagy.
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Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy.
Cardiovasc Res. 2012 Feb 1;93(2):320-9. doi: 10.1093/cvr/cvr321. Epub 2011 Dec 1.
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IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease.
J Clin Invest. 2011 Oct;121(10):4070-81. doi: 10.1172/JCI46305. Epub 2011 Sep 19.
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PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy.
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Blood glucose in the neonate and its clinical significance.
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Cardiac anaplerosis in health and disease: food for thought.
Cardiovasc Res. 2011 May 1;90(2):210-9. doi: 10.1093/cvr/cvr055. Epub 2011 Mar 11.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
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