Raeva S
Electroencephalogr Clin Neurophysiol. 1986 Feb;63(2):160-73. doi: 10.1016/0013-4694(86)90009-x.
Microelectrode recordings in the rostral (n. reticularis) and lateral (ventralis lateralis) human thalamus were carried out in locally anaesthetized diskinetic patients during stereotaxic operations. Their responses to voluntary motor tasks prompted by imperative verbal stimuli were tested. Spontaneous and evoked unit activities were studied using computer processing techniques. In the n. reticularis thalami and immediately adjacent thalamic zones, not only units reacting during the initiation of voluntary movements (100-200 msec before the movement), but also units responding to the verbal command itself ('triggered verbal command' units) were found. They proved to be concerned directly with the semantic meaning of the command. In the VL anterior area (Voa-Vop in German nomenclature) the majority of the units responded during the phases of initiation and/or realization of the voluntary motor act ('voluntary movement' units of Jasper and Bertrand 1966); when these units were not spontaneously rhythmic they were transiently transformed into rhythmic (5 +/- 1 Hz) ones. This transformation appeared during the preparation and realization of movement but also in some cells as a rebound phenomenon. In patients without tremor (akinetic and rigid forms of parkinsonism, torticollis), the transient rhythmogenic transformation was frequently provoked by the repetition of motor tasks. In the posterior part of VL (Vim), cells were driven by proprioceptive inflow coming from a specific peripheral region. They react also during the voluntary movement of the same region. The majority of these units were rhythmic at 5 +/- 1 Hz, and they presented a close correlation in phase and frequency with the tremor. The anatomical locations of the three main pools of neurons were determined. 'Triggered verbal command' units were placed more anteriorly and laterally. 'Voluntary movements' and 'rhythmic 5 +/- 1 Hz units' had identical spatial localizations. This fact supports the contributions of these two last types to the central mechanisms of both tremor and voluntary movement.
在立体定向手术过程中，对局部麻醉的运动障碍患者的丘脑嘴侧（网状核）和外侧（腹外侧核）进行了微电极记录。测试了他们对命令性言语刺激引发的自主运动任务的反应。使用计算机处理技术研究了自发和诱发的单位活动。在丘脑网状核及其紧邻的丘脑区域，不仅发现了在自主运动启动时（运动前100 - 200毫秒）做出反应的单位，还发现了对言语指令本身做出反应的单位（“触发言语指令”单位）。事实证明，它们与指令的语义直接相关。在腹外侧核前部区域（德语命名法中的Voa - Vop），大多数单位在自主运动行为的启动和/或执行阶段做出反应（贾斯珀和伯特兰1966年的“自主运动”单位）；当这些单位不是自发节律性时，它们会短暂转变为节律性（5±1赫兹）单位。这种转变在运动的准备和执行过程中出现，在一些细胞中也表现为一种反弹现象。在无震颤患者（帕金森病的运动不能和强直形式、斜颈）中，运动任务的重复经常引发短暂的节律性转变。在腹外侧核后部（Vim），细胞由来自特定外周区域的本体感觉传入驱动。它们在同一区域的自主运动过程中也会做出反应。这些单位中的大多数在5±1赫兹时有节律，并且它们在相位和频率上与震颤密切相关。确定了三个主要神经元池的解剖位置。“触发言语指令”单位位置更靠前且靠外侧。“自主运动”和“5±1赫兹节律性单位”具有相同的空间定位。这一事实支持了后两种类型对震颤和自主运动的中枢机制的作用。
