Al-Anazi Khalid A, Al-Jasser Asma M, Abdulwahab Amal, Sahovic Entezam, Almana Hadeel, Al Fadda Mohammed A
Section of Adult Hematology and Hematopoietic Stem Cell Transplant, King Faisal Cancer Centre, King Faisal Specialist Hospital and Research Centre, P.O. Box: 3354, Riyadh 11211, Saudi Arabia.
Clin Med Case Rep. 2008 Jul 29;1:101-5. doi: 10.4137/ccrep.s838. eCollection 2008.
Recipients of allogeneic hematopoietic stem cell transplant can develop life-threatening complications at any time following their transplants. These complications require repeated clinical assessment, appropriate and thorough screening as well as a comprehensive management approach. We report a young adult male who received a sibling allograft in the second complete remission of his acute lymphoblastic leukemia at King Faisal Specialist Hospital and Research Centre in Riyadh. The patient developed severe colitis which was caused by: acute exacerbation of chronic graft versus host disease of the lower gastrointestinal tract, cytomegalovirus disease of the colon and a superadded Salmonella infection caused by food poisoning. The multifactorial colitis was properly investigated and successfully managed. To our knowledge, this is the first case of multifactorial colitis in a recipient of hematopoietic stem cell transplant.
接受异基因造血干细胞移植的患者在移植后的任何时候都可能出现危及生命的并发症。这些并发症需要反复进行临床评估、适当且全面的筛查以及综合管理方法。我们报告一名年轻成年男性，他在利雅得的法赫德国王专科医院和研究中心，于急性淋巴细胞白血病第二次完全缓解期接受了同胞异体移植。该患者出现了严重结肠炎，其病因包括：下消化道慢性移植物抗宿主病急性加重、结肠巨细胞病毒病以及食物中毒导致的叠加沙门氏菌感染。对这种多因素导致的结肠炎进行了恰当的调查并成功进行了处理。据我们所知，这是造血干细胞移植受者中首例多因素结肠炎病例。
