Al-Anazi Khalid A, Jafar Saleh Abu, Al-Jasser Asma M, Al-Omar Hamad, Al-Mohareb Fahad I
Section of Adult Hematology and Hematopoietic, Stem Cell Transplant, King Faisal Cancer Centre, King Faisal Specialist Hospital and Research Centre, P,O, Box: 3345, Riyadh 11211, Saudi Arabia.
Cases J. 2009 Jan 27;2(1):91. doi: 10.1186/1757-1626-2-91.
Brucellosis is an important cause of morbidity and mortality in patients living in areas that are endemic for the infection.
A 20 years old Saudi male was diagnosed to have severe aplastic anemia at King Faisal Specialist Hospital and Research Centre in Riyadh in April 2006. One hundred and twelve days following his successful allogeneic hematopoietic stem cell transplant, he presented with pyrexia in addition to neutropenia and mild thrombocytopenia. Brucella serology was strongly positive and blood cultures grew Brucella melitensis. The bacteremic episode of brucellosis was successfully treated with streptomycin, doxycyclin and ciprofloxacin at the outpatient clinic. To our knowledge, this is the first case of a naturally occurring Brucella infection complicated by Brucella bacteremia in a recipient of hematopoietic stem cell transplant.
Brucellosis may cause systemic infections, complicated bacteremias and serious morbidity in immunocompromised patients living in countries that are endemic for the infection. It should be considered as a possible cause of fever and pancytopenia in hematopoietic stem cell transplant recipients living in these geographical locations. Nevertheless, the infection is curable provided the diagnosis is made early and an appropriate antimicrobial therapy is promptly initiated.
布鲁氏菌病是感染流行地区患者发病和死亡的重要原因。
一名20岁的沙特男性于2006年4月在利雅得的法赫德国王专科医院和研究中心被诊断为严重再生障碍性贫血。在成功进行异基因造血干细胞移植112天后，他除了出现中性粒细胞减少和轻度血小板减少外，还出现发热。布鲁氏菌血清学检测呈强阳性，血培养培养出羊布鲁氏菌。布鲁氏菌病的菌血症发作在门诊用链霉素、强力霉素和环丙沙星成功治疗。据我们所知，这是造血干细胞移植受者中首例自然发生的布鲁氏菌感染并发布鲁氏菌菌血症的病例。
布鲁氏菌病可能导致生活在感染流行国家的免疫功能低下患者发生全身感染、复杂性菌血症和严重发病。对于生活在这些地区的造血干细胞移植受者，应将其视为发热和全血细胞减少的可能原因。然而，只要早期诊断并及时开始适当的抗菌治疗，感染是可以治愈的。
