Kimura M, Nakamura M, Nagase M, Hishida A, Honda N
Jpn J Exp Med. 1985 Jun;55(3):89-98.
The influence of functional impairment of reticuloendothelial system on glomerular deposition of heat aggregated human IgG (HAIgG) was studied. I-125 HAIgG was injected to mice treated either with dextran-containing 0.9% saline or with the saline alone. The HAIgG clearance rate from the blood decreased in the dextran-treated mice. The chronologically measured HAIgG contents in the liver, spleen and glomeruli increased in the dextran-treated animals. Immunofluorescent technique also demonstrated an increase in HAIgG and host C3 in the glomeruli. The glomerular hypercellularity was not demonstrated morphologically. Assuming that the function of the hepatic Kupffer cells principally affect the clearance rate of the foreign macromolecules from the blood, it is likely that the dextran administration impaired the function of these cells to digest the phagocytosed HAIgG, and that consequently the injected HAIgG stayed longer in the blood. Thus, increased supply of the HAIgG from the blood and/or the dextran-induced reduction of digesting function of the mesangial cell per se might have led to the accumulation of glomerular HAIgG. We suggest, therefore, that even small amount of immune complex may induce immune complex-mediated glomerular lesion, when associated with long lasting functional impairment of the Kupffer cells.
研究了网状内皮系统功能损害对热聚集人IgG（HAIgG）肾小球沉积的影响。将I-125标记的HAIgG注射到用含右旋糖酐的0.9%盐水或仅用盐水处理的小鼠体内。在右旋糖酐处理的小鼠中，血液中HAIgG的清除率降低。右旋糖酐处理的动物肝脏、脾脏和肾小球中按时间顺序测量的HAIgG含量增加。免疫荧光技术也显示肾小球中HAIgG和宿主C3增加。未在形态学上证实肾小球细胞增多。假设肝库普弗细胞的功能主要影响血液中外源大分子的清除率，那么很可能右旋糖酐的给药损害了这些细胞消化吞噬的HAIgG的功能，结果注射的HAIgG在血液中停留的时间更长。因此，血液中HAIgG供应的增加和/或系膜细胞本身右旋糖酐诱导的消化功能降低可能导致肾小球HAIgG的积累。因此，我们认为，当与库普弗细胞长期功能损害相关时，即使少量免疫复合物也可能诱导免疫复合物介导的肾小球病变。
