Hoffsten P E, Swerdlin A, Bartell M, Hill C L, Venverloh J, Brotherson K, Klahr S
Kidney Int. 1979 Feb;15(2):144-59. doi: 10.1038/ki.1979.20.
The function of the mesangial and reticuloendothelial system was evaluated in normal mice and in mice with nephritis induced by lymphocytic choriomeningitis (LCM) virus infection. Heat-aggregated human immunoglobulin (AlgG) and colloidal carbon served as traceable materials which could be detected in animals' blood and tissues. LCM virus-infected proteinuric (LCM-P) mice, as compared to normal mice or LCM-infected nonproteinuric (LCM) mice, had greater accumulation of AIgG in their glomeruli at all times of examination following i.p. injection of AIgG. The removal rate of AIgG from the kidney, however, was the same in normal and LCM-P mice, indicating an unimpaired mesangial clearing system. This suggested that other mechanisms were responsible for the increased glomerular accumulation of AIgG in LCM-P mice. Reticuloendothelial function was examined directly by i.v. injection of AIgG or colloidal carbon. The data demonstrate that in this model of immune complex glomerulonephritis, colloidal material tested was removed from the blood at a slower rate than it was in normal mice. Deficient clearance of endogenous blood-borne immune complex-like material may be one of the factors playing a role in the accumulation of immune complex-like material in the glomeruli of these nephritic animals.
在正常小鼠以及由淋巴细胞性脉络丛脑膜炎（LCM）病毒感染诱发肾炎的小鼠中，对系膜和网状内皮系统的功能进行了评估。热聚集人免疫球蛋白（AlgG）和胶体碳作为可在动物血液和组织中检测到的可追踪物质。与正常小鼠或LCM感染的非蛋白尿（LCM）小鼠相比，LCM病毒感染的蛋白尿（LCM-P）小鼠在腹腔注射AlgG后的所有检查时间点，其肾小球中AlgG的积累都更多。然而，正常小鼠和LCM-P小鼠肾脏中AlgG的清除率是相同的，这表明系膜清除系统未受损。这表明其他机制导致了LCM-P小鼠肾小球中AlgG积累增加。通过静脉注射AlgG或胶体碳直接检测网状内皮功能。数据表明，在这种免疫复合物肾小球肾炎模型中，所检测的胶体物质从血液中清除的速度比正常小鼠慢。内源性血源免疫复合物样物质清除不足可能是这些肾炎动物肾小球中免疫复合物样物质积累的因素之一。
