Department of Neurology, Mayo Clinic, Rochester, MN; Department of Clinical Neuroscience, University of North Dakota School of Medicine and Health Sciences, Fargo, ND.
Mayo Clin Proc. 2013 Nov;88(11):1222-30. doi: 10.1016/j.mayocp.2013.08.012.
To investigate the association of chronic obstructive pulmonary disease (COPD) with mild cognitive impairment (MCI) and MCI subtype: amnestic MCI and nonamnestic MCI, in a population-based study of elderly patients.
Participants included 1927 individuals aged 70 to 89 years enrolled in the population-based Mayo Clinic Study of Aging. Participants were evaluated by using a nurse assessment, neurological evaluation, and neuropsychological testing, and the diagnosis of MCI was made by a consensus panel according to the standardized criteria. Chronic obstructive pulmonary disease was identified by the review of medical records. The study was conducted from October 1, 2004, through July 31, 2007. The associations of COPD and disease duration with MCI and its subtypes were evaluated by using logistic regression models adjusted for potential covariates.
Of 1927 participants, 288 had COPD (men vs women: 18% vs 12%; P<.001). As compared with patients without COPD, patients with COPD had a higher prevalence of MCI (27% vs 15%; P<.001). The odds ratio (OR) for MCI was almost 2 times higher in patients with COPD than in those without (OR, 1.87; 95% CI, 1.34-2.61), with a similar effect in men and women. The OR for MCI increased from 1.60 (95% CI, 0.97-2.57) in patients with a COPD duration of 5 years or less to 2.10 (95% CI, 1.38-3.14) in patients with a COPD duration of more than 5 years.
This population-based study suggests that COPD is associated with increased odds of having MCI and its subtypes. There was a dose-response relationship with the duration of COPD after controlling for the potential covariates.
在一项针对老年人群的基于人群的研究中，调查慢性阻塞性肺疾病（COPD）与轻度认知障碍（MCI）以及 MCI 亚型（遗忘型 MCI 和非遗忘型 MCI）之间的关联。
研究对象包括参加基于人群的 Mayo 诊所衰老研究的 1927 名年龄在 70 至 89 岁之间的个体。通过护士评估、神经学评估和神经心理学测试对参与者进行评估，并根据标准化标准由共识小组做出 MCI 的诊断。通过审查病历来确定 COPD。该研究于 2004 年 10 月 1 日至 2007 年 7 月 31 日进行。通过调整潜在协变量的逻辑回归模型评估 COPD 和疾病持续时间与 MCI 及其亚型的关联。
在 1927 名参与者中，有 288 名患有 COPD（男性与女性：18%比 12%；P<.001）。与没有 COPD 的患者相比，患有 COPD 的患者 MCI 的患病率更高（27%比 15%；P<.001）。与没有 COPD 的患者相比，患有 COPD 的患者发生 MCI 的几率几乎高出 2 倍（OR，1.87；95%CI，1.34-2.61），男性和女性的效果相似。在 COPD 持续时间为 5 年或以下的患者中，OR 为 1.60（95%CI，0.97-2.57），在 COPD 持续时间超过 5 年的患者中，OR 为 2.10（95%CI，1.38-3.14）。
这项基于人群的研究表明，COPD 与发生 MCI 及其亚型的几率增加有关。在控制潜在协变量后，与 COPD 的持续时间存在剂量反应关系。
