Cheng Yuan-Yang, Lin Shih-Yi, Hsu Chiann-Yi, Fu Pin-Kuei
Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402010, Taiwan.
J Pers Med. 2022 Mar 16;12(3):475. doi: 10.3390/jpm12030475.
Patients with chronic obstructive pulmonary disease (COPD) are frequently comorbid with mild cognitive impairment (MCI). Whether respiratory muscle training (RMT) is helpful for patients with COPD comorbid MCI remains unclear. Inspiratory muscle training (IMT) with or without expiratory muscle training (EMT) was performed. Patients were randomly assigned to the full training group (EMT + IMT) or the simple training group (IMT only). A total of 49 patients completed the eight-week course of RMT training. RMT significantly improved the maximal inspiratory pressure (MIP), the diaphragmatic thickness fraction and excursion, lung function, scores in the COPD assessment test (CAT), modified Medical Research Council (mMRC) scale scores, and MMSE. The between-group difference in the full training and single training group was not significant. Subgroup analysis classified by the forced expiratory volume in one second (FEV1) level of patients showed no significant differences in MIP, lung function, cognitive function, and walking distance. However, a significant increase in diaphragmatic thickness was found in patients with FEV1 ≥ 30%. We suggest that patients with COPD should start RMT earlier in their disease course to improve physical activity.
慢性阻塞性肺疾病（COPD）患者常合并轻度认知障碍（MCI）。呼吸肌训练（RMT）对合并MCI的COPD患者是否有帮助尚不清楚。进行了有或没有呼气肌训练（EMT）的吸气肌训练（IMT）。患者被随机分配到完全训练组（EMT + IMT）或单纯训练组（仅IMT）。共有49名患者完成了为期八周的RMT训练。RMT显著改善了最大吸气压（MIP）、膈肌厚度分数和偏移、肺功能、慢性阻塞性肺疾病评估测试（CAT）得分、改良医学研究委员会（mMRC）量表得分和简易精神状态检查表（MMSE）。完全训练组和单一训练组之间的组间差异不显著。按患者一秒用力呼气量（FEV1）水平进行的亚组分析显示，MIP、肺功能、认知功能和步行距离无显著差异。然而，FEV1≥30%的患者膈肌厚度显著增加。我们建议COPD患者应在病程早期开始RMT以改善身体活动。
