Deville J-L, Flechon A, Bruyère F, Karsenty G, Guy L, Bastide C
Service d'oncologie, hôpital de la Timone, Aix-Marseille université, AP-HM, 13385 Marseille cedex 5, France.
Prog Urol. 2013 Nov;23(15):1265-70. doi: 10.1016/j.purol.2013.08.321. Epub 2013 Oct 2.
To describe drugs used in the chemotherapy of testis and penis neoplasms.
Bibliographical search was performed from the database Medline (National Library of Medicine, PubMed) and websites of the HAS and the ANSM. The search was focused on the characteristics, the mode of action, the efficiency and the side effects of the various drugs concerned.
Nowadays, the chemotherapy is perfectly codified in adjuvant treatment or in first-line treatment of metastatic testis cancer. A single dose of carboplatin for seminoma testicular (stage I) in adjuvant treatment situation is one of the latest advances. Concerning penis cancer, the optimal protocols validated by a high level of evidence are missing.
The chemotherapy in testis and penis neoplasms knew few advances in recent years. So, it is necessary to include patients in clinical research protocols.
描述用于睾丸和阴茎肿瘤化疗的药物。
通过医学数据库(美国国立医学图书馆,PubMed)以及法国卫生安全局(HAS)和法国药品安全局(ANSM)的网站进行文献检索。检索重点在于各种相关药物的特性、作用方式、疗效和副作用。
如今,化疗在转移性睾丸癌的辅助治疗或一线治疗中已有完善的规范。辅助治疗时,单剂量卡铂用于睾丸精原细胞瘤(I期)是最新进展之一。关于阴茎癌,缺乏经高水平证据验证的最佳方案。
近年来,睾丸和阴茎肿瘤的化疗进展甚微。因此,有必要让患者参与临床研究方案。