Ogawa M, Matsuda K, Matsuda Y, Nakaguchi K, Miyauchi K, Nishijima J, Mori T, Horikawa Y, Kurihara M
Nihon Geka Gakkai Zasshi. 1985 Sep;86(9):1241-4.
Serum pancreatic enzymes (amylase, trypsin, pancreatic elastase 1, pancreatic phospholipase A2) and serum pancreatic secretory trypsin inhibitor (PSTI) were measured in 22 patients with moderate or severe acute pancreatitis. Serum levels of all pancreatic enzymes were elevated at the initial determination, but they fell rapidly to normal in both moderate and severe pancreatitis. In contrast, PSTI in severe pancreatitis increased after admission and reached the maximum on the second to the forth day after onset. There was a significant positive correlation between the level of PSTI and that of acute phase reactant (fibrinogen, alpha 1-antitrypsin), and serum PSTI in severe acute pancreatitis changed as if it was one of acute phase reactants. There was also a significant negative correlation between the level of serum PSTI and that of alpha 2-macroglobulin.
对22例中度或重度急性胰腺炎患者测定了血清胰腺酶（淀粉酶、胰蛋白酶、胰腺弹性蛋白酶1、胰腺磷脂酶A2）和血清胰腺分泌性胰蛋白酶抑制剂（PSTI）。所有胰腺酶的血清水平在初次测定时均升高，但在中度和重度胰腺炎中均迅速降至正常。相比之下，重度胰腺炎患者入院后PSTI升高，并在发病后第二至第四天达到最高值。PSTI水平与急性期反应物（纤维蛋白原、α1-抗胰蛋白酶）水平之间存在显著正相关，重度急性胰腺炎患者的血清PSTI变化似乎与急性期反应物之一相似。血清PSTI水平与α2-巨球蛋白水平之间也存在显著负相关。
