Matsuda Y, Ogawa M, Nishijima J, Miyauchi K, Mori T
Hepatogastroenterology. 1986 Oct;33(5):214-6.
To investigate the correlation between the initial levels of serum pancreatic enzymes and the severity of acute pancreatitis, serum amylase activity, immunoreactive trypsin content, phospholipase A2 activity and immunoreactive pancreatic phospholipase A2 content were comparatively measured in 22 patients with acute pancreatitis. Serum immunoreactive pancreatic phospholipase A2 content and phospholipase A2 activity in the severe group were significantly elevated as compared with those in the group of moderate pancreatitis on the first day of onset. The elevation of the initial immunoreactive phospholipase A2 content in the severe group was far greater than that of amylase activity, trypsin content and phospholipase A2 activity. The difference between immunoreactive phospholipase A2 content and phospholipase A2 activity was, in part, due to the presence of prophospholipase A2 in severe acute pancreatitis sera, but the phospholipase A2 content measured by radioimmunoassay was still about 5 times higher than that calculated from fully activated phospholipase A2 activity by trypsin.
为研究血清胰酶初始水平与急性胰腺炎严重程度之间的相关性，对22例急性胰腺炎患者的血清淀粉酶活性、免疫反应性胰蛋白酶含量、磷脂酶A2活性及免疫反应性胰腺磷脂酶A2含量进行了比较测定。在发病第一天，重症组血清免疫反应性胰腺磷脂酶A2含量及磷脂酶A2活性较中度胰腺炎组显著升高。重症组初始免疫反应性磷脂酶A2含量的升高幅度远大于淀粉酶活性、胰蛋白酶含量及磷脂酶A2活性。免疫反应性磷脂酶A2含量与磷脂酶A2活性之间的差异，部分归因于重症急性胰腺炎血清中存在前磷脂酶A2，但通过放射免疫测定法测得的磷脂酶A2含量仍比根据胰蛋白酶完全激活的磷脂酶A2活性计算出的含量高约5倍。
