Stewart J C, Regezi J A, Lloyd R V, McClatchey K D
Oral Surg Oral Med Oral Pathol. 1986 Jan;61(1):48-53. doi: 10.1016/0030-4220(86)90202-1.
Recent evidence suggests that the proliferative cells of idiopathic histiocytosis may be derived from Langerhans cells. In this study, antisera to S-100 protein, HLA-DR (la-like) antigen, muramidase, and alpha 1-antichymotrypsin were tested on formalin-fixed, paraffin-embedded tissue from nine cases of idiopathic histiocytosis using an immunoperoxidase technique. Tumor cells were positive for S-100 protein and HLA-DR antigen but negative for muramidase and alpha 1-antichymotrypsin. Mononuclear phagocytes were positive for HLA-DR antigen, muramidase, and alpha 1-antichymotrypsin but negative for S-100 protein. The immunohistochemical staining pattern of the tumor cells in these cases of idiopathic histiocytosis is similar to that seen for normal Langerhans cells. When these results are coupled with electron microscopic and histochemical data, it would appear that the origin of cells in idiopathic histiocytosis is from the Langerhans cell or its precursor. Thus, this condition might be better designated "Langerhans cell disease."
近期证据表明，特发性组织细胞增多症的增殖细胞可能来源于朗格汉斯细胞。在本研究中，采用免疫过氧化物酶技术，对9例特发性组织细胞增多症福尔马林固定、石蜡包埋组织进行了S-100蛋白、HLA-DR（类la）抗原、溶菌酶和α1-抗糜蛋白酶抗血清检测。肿瘤细胞S-100蛋白和HLA-DR抗原呈阳性，但溶菌酶和α1-抗糜蛋白酶呈阴性。单核吞噬细胞HLA-DR抗原、溶菌酶和α1-抗糜蛋白酶呈阳性，但S-100蛋白呈阴性。这些特发性组织细胞增多症病例中肿瘤细胞的免疫组化染色模式与正常朗格汉斯细胞相似。当这些结果与电子显微镜和组织化学数据相结合时，特发性组织细胞增多症的细胞起源似乎来自朗格汉斯细胞或其前体。因此，这种情况可能更宜称为“朗格汉斯细胞病”。
